Delalande S.a.

Delande S.a.

Guy R Bourgery

Alain P Lacour

Philippe L Dostert

Colette A Douzon

Claude P Fauran

Patrick G Guerret

Bernard M Pourrias

Michel Langlois

Guy M Raynaud

Claude J Gouret

Jean-Francois R Ancher

Gerard H Moinet

Jeannine A Eberle

Gisele C Mocquet

Raphael Santamaria

Phillippe L Dostert

Alain Y Platel

Nicole A Dorme

Claude G Gouret

Genevieve C Bregeon

Anne-Marie P Ruch

Jean A Coston

Margherita Strolin-Benedetti

Guy R Raynaud

Jean-Alain Coston

Alain Lacour, Deceased

New aromatic derivatives having an activity antagonistic to calcium and corresponding to formula: ##STR1## in which: A represents a chain having any one of the following structures: ##STR2## Ar represents a group of structure: ##STR3## n takes the value 1 or 2 when R is different from H; m takes the value 2 or 3.

Aromatic derivatives comprising an aminoalkoxy chain, the salts thereof,

Compounds of formula: ##STR1## wherein: Ar is an aromatic group; R and R.sub.1 are H or CH.sub.3 ; A represents a nitrogenized heterocyclic radical; B is OH or forms with the adjacent CO group, either an amido group, or a carbonyloxy group; R.sub.2 and R.sub.3 are H or alkyl; m=0 or 1; and n=0, 1, 2 or 3. These compounds are useful as drugs having stimulating, protecting and/or correcting activities of the cerebral functions.

New cinnamoic compounds, the process for preparing same and the use

New derivatives are provided corresponding to the formula: ##STR1## in which Ar represents an aromatic nucleus; and X represents: either the trans ##STR2## chain or the ##STR3## chain and A=CONHOH, COOEt, COOH or CONR.sub.2 R.sub.3, either the trans-CH.dbd.CH--CH.sub.2 -- chain or --CH.sub.2 --CH.sub.2 --CH.sub.2 chain and A=carboxamido, N-isopropylcarboxamido, pyrrolidinocarbonyl or piperidinocarbonyl. These derivatives and their salts are used as drug for their activity stimulating, protecting and/or correcting cerebral functions.

Arylic derivatives of piperazine, the method of preparing same and their

Aromatic derivatives comprising an aminoalkoxy chain and pharmaceutical

N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones are disclosed. These compounds possess antidepressant activity.

N-Substituted phenyl-5-aminomethyl oxazolidinones and their method of use

A compound of the formula ##STR1## where R is selected from the group consisting of CH.sub.3 --CO--(CH.sub.2).sub.2 --O--, ##STR2## The compounds are useful in treating depression.

-N-substituted phenyl-5-methoxymethyl-2-oxazolidinones and

The present invention concerns novel heterocyclic aminoalcoyl derivatives having the formula: ##STR1## wherein n=1, 2 or 3; A represents a nitrogen atom or the CH group, X=CH.sub.2 or CH.sub.2 O; R represents a phenyl nucleus possibly substituted; NR.sub.1 R.sub.2 =amino, methylamino, N,N-dialkylamino or an heterocyclic radical; and R.sub.3 =H, halogen, alkyl, alkyloxy or methoxy. These derivatives are useful as drugs, especially as analgesics and antidepressants.

3-Hydroxyalkyl-3,4-dihydro-1-substituted isoquinolines

A class of known (1-cinnamoyl or 1-phenylethylcarbonyl) piperazine derivatives have been found to be central nervous system stimulants effective to improve the mental alertness and to brighten the spirits of human beings.

Therapeutical use of (1-cinnamoyl or 1-phenethylcarbonyl) piperazine

Method of treating the central nervous system troubles such as the Parkinson's disease and the senescence troubles, generally treated by the B type monoamine oxidase inhibitors, which comprises administering internally to a human being requiring such treatment a therapeutically effective amount of N-aryl 5-aminomethyl oxazolidine-2-one derivatives.

Therapeutical use of known 5-aminomethyl oxazolidine-2-one derivatives

N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines

The present invention concerns compounds of the formula ##STR1## wherein n=1, 2 or 3; and R' represents phenyl or orthofluorophenyl. Said compounds are used as intermediates in the preparation of heterocyclic aminoalkyl derivatives which are useful as analgesics and antidepressants.

3-(Hydroxyalkyl)-3,4-dihydro-1-orthohalophenyl naphthalenes

The present invention concerns heterocyclic aminoalcoyl derivatives having the formula: ##STR1## wherein n=1, 2 or 3; A represents a nitrogen atom or the CH group, X=CH.sub.2 or CH.sub.2 O; R represents a phenyl nucleus possibly substituted; NR.sub.1 R.sub.2 =amino, methylamino, N,N-dialkylamino or an heterocyclic radical; and R.sub.3 =H, halogen, alkyl, alkyloxy or methoxy. These derivatives are useful as drugs, especially as analgesics and antidepressants.

Nitrogen containing 2,3-dihydro naphthalenes, compositions and use

Growing community of inventors

Colombes, France

Guy R Bourgery