Hoffmann-la Roche Inc.

Guy P Heathers

Jefferson Wright Tilley

Richard W Kierstead

Robert W Guthrie

Ronald A LeMahieu

John G Mullin

David F Kachensky

Alan J Higgins

The invention relates to compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate, enantiomers, racemates, diastereomers or mixtures thereof or geometric isomer or mixtures thereof, and pharmaceutically acceptable salts thereof. The compounds of formula I inhibit enzyme carnitine acyltransferase 1 (CAT-1) and are therefore useful in the prevention of injury to ischemic tissue, and can limit infarct size, improve cardiac function and prevent arrhythmias during and following a myocardial infarction.

Cat-1 inhibitors, pharmaceutical compositions and methods of use

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Morristown, NJ, United States of America

Guy P Heathers