Delalande S.a.

Guy P Adrian

Sylvain G Garnier

Method of preparing 4-disubstituted phenyl-1-tetralones of formula ##STR1## in which X represents halogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy and Y, situated in position 2' or 3', represents halogen or C.sub.1 -C.sub.4 alkyl, this method being characterized in that it comprises the reaction, in the presence of an acid agent, of .alpha.-naphthol of formula (II) with a phenyl compound of formula (III): ##STR2## where X represents halogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, and Y is situated in the ortho or meta position with respect to X and represents halogen or C.sub.1 -C.sub.4 alkyl.

Method of preparing 4-dichlorophenyl-1-tetralones

The present invention provides a process for preparing 6-(lower)alkoxy-1-naphthoic acids, the corresponding esters and 5-halo substituted derivatives thereof. The process comprises reacting furoic acid with an alkoxyphenyl compound, followed by acid hydrolysis to form a mixture of alkoxy and hydroxy substituted naphthoic acids, subjecting said mixture to the action of an alkylating agent, and optionally further treating the alkylated product to another hydrolysis step or a halogenation step.

Process for preparing 6-(lower) alkoxy-1-naphthoic acids and the

A process for preparing hydratropic acids and the esters thereof, of formula Ar--CH(CH.sub.3)--COOR where R=H or lower alkyl and Ar=phenyl possibly substituted. This process consists in reacting on the propiophenones of formula ArCOCH.sub.2 CH.sub.3, a chlorinating or brominating agent, an alcohol R'OH where R'=lower alkyl, an orthoester R.sub.1 --C(OR').sub.3 wherein R.sub.1 =H or lower alkyl, and metal zinc; then possibly hydrolyzing the esters obtained. With this process can be prepared hydratropic acids known for their anti-inflammatory activity.

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Givors, France

Guy P Adrian