The Genetics Company, Inc.

Guy Lemaillet

Frank Jaschinski

Leonardo Scapozza

Barbara Froesch

Pierre Daram

Gabriel Garcia

Cornelia Marty-Ernst

Elena Marzi

The present invention relates to the use of a sulfonamide compound of formula (I): wherein Ris selected from the group consisting of H, CN, halogen, trifluoromethyl, methyl, ethyl, hydroxy, methoxy, ethoxy, morpholino, Ris selected from H, phenyl, substituted phenyl, CN, &#x2014;SOR, wherein R is phenyl or morpholino, &#x2014;NC(O)Me, &#x2014;NC(O)Et, &#x2014;CHC(O)OMe, CHC(O)OEt, Ris selected from the group consisting of H, NO, NH, halogen, &#x2014;COOMe, &#x2014;COOEt, RC(O)N&#x2014;, morpholino, Ris selected from the group consisting of H, a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, methoxy, ethoxy, propoxy, butoxy, a substituted or unsubstituted phenyl, alkinyl, MeSO&#x2014;, COOR, wherein R is a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, -MeOC(O)&#x2014;, a substituted or unsubstituted five or sixmembered aromatic or non-aromatic heterocyclic system with one, two or three heteroatoms, a hetaryl system, a condensed benzoheterocyclic system, X is a linker comprising 2 or 3 atoms, selected from the group consisting of &#x2014;NH&#x2014;NH&#x2014;, &#x2014;NH&#x2014;NH&#x2014;CH2&#x2014;, ethinyl, &#x2014;NH&#x2014;C(O)&#x2014;CH&#x2014;, &#x2014;NH&#x2014;NH&#x2014;SO&#x2014;, &#x2014;C(O)&#x2014;NH&#x2014;CH&#x2014;, &#x2014;NH&#x2014;N&#x2550;CH&#x2014;, &#x2014;NH&#x2014;N&#x2550;C(Me)-, a &#x2014;NH&#x2014;N&#x2550;CH&#x2014; motif being part of a heterocyclic system, preferably a substituted or unsubstituted pyrazole or pyridazine system, and pharmaceutically active salts thereof. Further, the invention relates to the use of these compounds as a medicament, especially for the treatment of cancer. 

Sulfonamides and their use as a medicament

Growing community of inventors

Meilen, Switzerland

Guy Lemaillet