Other

Angiogene Inc.

Centre De Recherche Du Centre Hospitalier De L'universite De Montreal

Guy Leclerc

Jean C Raymond

Nabil G Seidah

Robert Day

R&eacute;mi Martel

Tim Reudelhuber

Michel Chr&eacute;tien

Remi Martel

The present invention relates to an occlusion device for treating an aneurysm, its use and a method for treating an aneurysm. The occlusion device comprises a detachable filling element and at least one radioactive source. The detachable filling element and the radioactive source are adapted to be inserted into a vessel at least in close proximity of a neck of an aneurysm. The radioactive source stimulates neointima formation for obstructing the neck of the aneurysm or filling up the aneurysm.

Occlusion device for treating aneurysm and use therefor

The present invention relates to the cloning of human pro-protein converting enzyme 5 (PC5) CDNA isolated from human adrenal gland messenger RNA. Additionally, this invention relates to a method for reducing restenosis occurring at an injured vascular site comprising delivering to the injured site an antisense nucleic acid to suppress the expression of human PC5.

Pro-protein converting enzyme

The present invention relates to a radiolabeled DNA oligonucleotide, a method of preparation thereof and the therapeutic uses of this substance to prevent uncontrolled cellular proliferation. The invention also relates to devices incorporating the above radiolabeled DNA oligonucleotide for the therapeutic treatment of uncontrolled cellular proliferation. More specifically, the present invention is concerned with the prevention of restenosis by coronary delivery of radiolabeled DNA oligonucleotide at a dilatation site of an artery. This invention is also directed to a method of treatment of vascular proliferative diseases and/or other proliferative disorders such as cancer and related metastasis. More particularly, the invention relates to the preparation of DNA sequences carrying one or several radioisotopes, located within the DNA sequence, and which are able to prevent cell proliferation in vitro and, pursuant to local drug delivery, are able to prevent cell proliferation in vivo, more particularly restenosis and malignant tumors. In other words, the invention relates to the synthesis process, the stability data of the radiolabeled DNA oligonucleotide, the efficacy of the invention in vitro, in cell culture, and the in vivo delivery of the molecule.

Radiolabeled DNA oligonucleotide and method of preparation

A check valve for removably fitting the mouth of an invertible water bottle to be placed on a water dispenser, the bottle being made of synthetic resin and provided with an external circular rib at its mouth. The valve closes the mouth during water-bottle inversion until the check valve contacts an element of the water dispenser when the bottle is in inverted position and rests on a water dispenser. The check valve includes a cylindrical body adapted to be removably fitted over the water bottle mouth and having an outer closure wall provided with a central opening forming a tapered female valve seat. The check valve further includes a male valve member part having a disc-like head axially movable within the body between the mouth and the closure wall, a stem secured to the head and extending through the central opening of the closure wall, and a tapered male valve seat portion integral with the stem and adjacent the head. Upon water-bottle inversion, the water in the bottle acts upon the valve head to close the valve. An inward force exerted on the stem opens the valve.

Growing community of inventors

Rosemère, Canada

Guy Leclerc