Neurowave Systems Inc.

Pulsar Informatics, Inc.

The University of British Columbia

Guy DuMont

Daniel Joseph Mollicone

Christopher Grey Mott

Mark Ansermino

Klaske Van Heusden

Diane Boivin

Nicholas West

The invention involves the administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention involves closed-loop control systems/methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures/indicia of analgesia. The invention further includes such control systems/methods that account for limitations of such indirect measures/indicia of analgesia.

Systems and methods for controlled delivery of analgesic and hypnotic agents

Systems and methods are provided for predicting a circadian state of an individual. The methods comprise: providing a model representative of the response of the circadian state to light stimulus, the model comprising at least one model variable representative of a probability distribution function (PDF) of a phase offset of the circadian state of the individual; and using the model to estimate an updated PDF of the phase offset, wherein using the model to estimate the updated PDF of the phase offset comprises performing a Bayesian estimation process commencing with an initial PDF of the phase offset and iterating toward the updated PDF of the phase offset.

Methods and systems for circadian physiology predictions

Growing community of inventors

Vancouver, Canada

Guy DuMont