Dsm IP Assets B.v.

Covestro (Netherlands) B.v.

Guy Draaisma

George Mihov

Silvana Rensina Antonnietta Di Silvestre

Tristan Handels

Jens Christoph Thies

Thijs Besseling

Peter Leonardus Elisabeth Maria Pasmans

Di Silvana Rensina Antonnietta Silvestre

Silvana Rensina Silvestre Di

A coated substrate comprising a coating layer comprising inorganic oxide and pores, the coating layer demonstrates improved durability properties. The coated substrate may for example be used in solar modules. Further a coating formulation and use of the coating formulation are disclosed.

Coating and coating formulation

The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.

Drug delivery system for delivery of acid sensitivity drugs

The present invention relates to a poly (ester amide) (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9 m+p+q=1 whereby m or p could be 0 n is about 5 to about 300; (pref. 50-200) Ris independently selected from the group consisting of (C-C) alkylene, (C-C) alkenylene, &#x2014;(R&#x2014;CO&#x2014;O&#x2014;R&#x2014;O&#x2014;CO&#x2014;R)&#x2014;, &#x2014;CHR&#x2014;O&#x2014;CO&#x2014;R&#x2014;COOCR&#x2014; and combinations thereof; Rand Rin a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C-C)alkyl, (C-C)alkenyl, (C-C)alkynyl, (C-C)aryl, (C-C)alkyl, &#x2014;(CH)SH, &#x2014;(CH)S(CH), &#x2014;CHOH, &#x2014;CH(OH)CH, &#x2014;(CH)NH+, &#x2014;(CH)NHC(&#x2550;NH+)NH, &#x2014;CHCOOH, &#x2014;(CH)COOH, &#x2014;CH&#x2014;CO&#x2014;NH, &#x2014;CHCH&#x2014;CO&#x2014;NH, &#x2014;CHCHCOOH, CH&#x2014;CH&#x2014;CH(CH)&#x2014;, (CH)&#x2014;CH&#x2014;CH&#x2014;, HN&#x2014;(CH)&#x2014;, Ph-CH&#x2014;, CH&#x2550;C&#x2014;CH&#x2014;, HO-p-Ph-CH&#x2014;, (CH)&#x2014;CH&#x2014;, Ph-NH&#x2014;, NH&#x2014;(CH)&#x2014;C&#x2014;, NH&#x2014;CH&#x2550;N&#x2014;CH&#x2550;C&#x2014;CH&#x2014;. Ris selected from the group consisting of (C-C)alkylene, (C-C)alkenylene, alkyloxy or oligoethyleneglycol Ris selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); Ris selected from the group consisting of (C-C)aryl (C-C)alkyl Ris (CH2)4-; Ror Rare independently selected from C-Calkylene or C-Calkenylene. Ror Rare independently selected from H, methyl, C-Calkylene or C-Calkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1. 

Biodegradable polyesteramide copolymers for drug delivery

The present invention relates to a poly (ester amide) (PEA) having a chemical formula described by structural formula (IV), wherein 

Drug delivery compositions are provided having proteins and biodegradable polymers that may be used for controlled and long term release of proteins into a biological environment. According to some embodiments, the drug delivery composition may be provided with at least a protein and a biodegradable polymer possessing at least two different functional groups selected from the group of chosen among carboxyl, ester, amine, amide, thiol, thioester or hydroxyl groups pendant to the main polymer chain whereby the composition absorbs between 5-10% w/w water when exposed to physiological conditions for at least 20 days. A drug delivery system for controlled protein release which includes the drug delivery composition is also provided whereby the drug delivery system may be in the form of microparticles, films, coatings, fibers, pellets, cylinders, discs, implants, microcapsules, microspheres, nanospheres, wafers, micelles, liposomes or woven or non-woven fabrics.

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Echt, Netherlands

Guy Draaisma