Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université De Nantes

New York University

Zimmer Gmbh

The University of Nantes

Biomatlante

Guy Daculsi

Jérôme Guicheux

Pierre Weiss

Bruno Bujoli

Jean-Michel Bouler

Pascal Janvier

Solen Josse

Joel Delecrin

Xavier Bourges

Ibrahim Khairoun

Racquel Z LeGeros

Gaël Grimandi

Catherine Deudon

Mieczyslam Lapkowski

Anne Dupraz

Francedillaois Guerin

Norbert Passuti

Bruno Duquet

Olivier Gauthier

Jean-Michael Bouler

Claire Vinatier

Serge Baroth

The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.

Use of a hydrogel for the culture of chondrocytes

A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.

Modified phosphocalcic compound, injectable composition containing same

The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.

A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.

Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment

Biomaterial composition and method for preparing same

Composition for biomaterial; preparation process

Process for the production of single- or multi-phase materials of

The coating for a prothesis system has a resorbability gradient in the direction perpendicular to the surface of the prothesis system, the internal layer being the least resorbable. It can consist of phospho-calcium material or of two or several successive layers having different resorbabilities and having said resorbability gradient. The prothesis systems covered with the coating according to the invention are used in surgery for the provision of thigh-bone protheses as well as protheses for the facial, ear, nose and throat surgery and the like.

Surface coating for prosthesis system containing HA/TCP composition

Growing community of inventors

Vigneux-de-Bretagne, France

Guy Daculsi