Laboratoires Pos

Laboratoirs Alcon S.a.

Laboratories Alcon S.a.

Guy Andermann

Georges De Burlet

Jacques Himber

Gerard LeClerc

Michel Dietz

Joseph Spittler

Catherine Cannet

Mohammed Bouzoubaa

Gerard Leclerc

Dominique Mergel

Didier Huber

Patricia Zilliox

Beatrice Ruhland

Claudine Andermann

Compounds which enhance the efficiency of the corneal endothelial fluid pump thereby promoting normal corneal function and deturgescence of swollen corneas, and methods for the compounds' synthesis are described. In addition, surgical irrigating solutions which include one or more of the compounds are discussed along with methods for their use.

Compounds having GABA like activity, and use of same in tissue

Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.

Imidazolines useful in lowering intraocular pressure

A system and method for disinfecting contact lenses with a stabilized hydrogen peroxide solution and a separate neutralizing solution are described. Sodium stannate (a.k.a. sodium tin oxide) is utilized to stabilize the hydrogen peroxide, and sodium thiosulfate is utilized to neutralize the hydrogen peroxide. In addition to sodium thiosulfate, the neutralizing solution also contains a complexing agent capable of sequestering tin, such as EDTA or EGTA. The system and method provide improvements over prior hydrogen peroxide disinfection systems with respect to stability, predictability and rate of reaction.

Hydrogen peroxide disinfecting system for contact lenses

A tissue irrigating solution useful for irrigating animal tissue, such as ocular tissue and neuro tissue, during surgery, contains sodium, potassium, magnesium calcium chloride, and bicarbonate ions as well as dextrose, glutathione, and gamma-amino butyric acid (GABA) or functional analogue(s) of GABA, or a mixture of GABA and such analogue(s) in proportions consistent with the osmotic stability and continued metabolism of the tissue cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.

Two part tissue irrigating solution

Glaucoma can be treated by the application to the eye of a physiologically active amount of a compound of the formula ##STR1## in which: each of R.sub.3 and R.sub.4 is selected from hydrogen, and alkyl, alkenyl and cycloalkyl radicals, or R.sub.3 and R.sub.4 together with the carbon between them are a cycloalkylidene radical,

Ethers and oxime ethers of alkylamino alcohols as medicaments and novel

A new composition consists of an eyewash in buffered saline solution, preferably aqueous having the desired isotonicity and in which the active agent consists of inosine monophosphate, preferably in the form of a disodium salt. It is applied to the treatment of human eye troubles such as: strabismus of various types, beginning presbyopia, heterophoria by convergence insufficiency exophoria, asthenopia by ametropia, fusion troubles in astigmats.

Growing community of inventors

Colmar, France

Guy Andermann