Societe Chimique De La Grande Paroisse, Azote Et Produits Chimiques

Guy Adrian

Marcel-Xavier Sion

Andre Benattar

The known compound 2-nitro-2-methyl-1-propanol is prepared by formylation, n crystalline form of high purity and in high yields, by reacting 2-nitropropane and formaldehyde in a molar ratio between 0.9:1 and 1.1:1, in a concentrated medium and in the presence of 1 to 10 milli-equivalents of an inorganic basic catalyst per mole of 2-nitropropane, with agitation, at a temperature between 40.degree. and 58.degree. C.; the pH of the reaction medium being between 7 and 11.

Preparation of 2-nitro-2-methyl-1-propanol

2-Amino-n-butanol is prepared by condensing 1-nitropropane with formaldehyde in an aqueous medium in the presence of a phase transfer agent which acts both as a basic catalyst and as a surfactant, and the resulting 2-nitro-n-butanol obtained is subjected to catalytic hydrogenation using a hydrogenating mixture consisting of hydrogen and nitrogen at a pressure of 8 to 12 bars.

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Lille, France

Guy Adrian