Nps Pharmaceuticals, Inc.

Ketogen Inc.

Guy A Higgins

Abdelmalik Slassi

Methvin Benjamin Isaac

Tao Xin

Subhash Annedi

Jaipal Reddy Nagireddy

Joseph A Araujo

John S Andrews

Methvin Issac

Gary L W G Robinson

Norton W Milgram

Paula J Estey

Subhash C Annedi

Gary Lwg Robinson

Jaipal R Nagireddy

The present application relates to novel compounds comprising a moiety that leads to the metabolic production of ketones bonded to a ketone-potentiated anti-epileptic drug, compositions comprising these compounds, and their use, for example for the treatment of epilepsy, and other CNS diseases, disorders or conditions. In particular, the present application includes compounds of Formula I, and compositions and uses thereof: 

Compounds for the treatment of seizures and other central nervous systems disorders and conditions

Compounds of Formula I are useful for the treatment of anxiety disorders such as generalized anxiety disorder (GAD), panic attack, post traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD) and social phobias. wherein: A is chosen from: aryl or heteroaryl, A being optionally substituted with up to 5 independently-selected groups R; Ris chosen from: alkyl or haloalkyl; Ris chosen from: H, C(O)R, C(O)OR, SO2Ror C(O)NRR; R, Rand Rare independently chosen from: H or alkyl; Rand Rare independently chosen from: H or alkyl; and Ris chosen from: OH, CN, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, C(O)R, C(O)OR, SO2Ror C(O)NRR. 

Use of D-serine derivatives for the treatment of anxiety disorders

Compounds of Formula I are useful in the treatment of epilepsy, neuropathic pain, acute and chronic inflammatory pain, migraine, tardive dyskinesia and other related CNS disorders. wherein:

Fluorinated compounds

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Toronto, Canada

Guy A Higgins