Terapia Celular, L'n, Inc.

Lnk Chemsolutions, LLC

Other

Kraft Foods Holdings, Inc.

Gustavo Larsen

David Vu

Ruben Spretz

Manuel Marquez-Sanchez

Raffet Velarde-Ortiz

Ahmad Akashe

Luis H Nunez

Raffett Velarde Ortiz

Rajinder S Gill

Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the signal amplifying molecule within its matrix and may also have antibodies affixed to its surface for molecular recognition. Ultrafine particles are also provided having a matrix component that includes a signal amplifying molecule and at least one antibody specific for the antigen or biomaterial. The ultrafine particles of the present disclosure may be used in assays for the detection, including quantification, of one or more antigens present in a biological sample.

Methods and materials for amplification of a signal in an immunoassay

Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.

Systems for producing multilayered particles, fibers and sprays and methods for administering the same

A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

Method of manufacturing fibrous hemostatic bandages

A method of making a pliable, bioabsorbable hemostatic dressing wherein the dressing is composed of fibers with at least one molecular-scale coating, which upon first contact with blood and due to a large area of contact with blood per unit weight of active ingredients, initiates and accelerates the biochemical blood clotting cascade processes. The steps of the method include dissolving in an organic solvent one or more soluble bioabsorbable polymers and organic or aqueous-organic media of non-protein constituents to create a homogeneous mixture; forming fibers from the homogeneous mixture; adding to the fibers a molecular-scale first coating of one or more proteins of blood clotting species that minimally react with each other; and optionally adding a second coating of one or more proteins of blood clotting species to the fibers that minimally react with each other and that, together with the one or more proteins of blood clotting species in the molecular-scale first coating, induce blood coagulation in the presence of blood. The fibers may optionally have occluded in them or at their surface other chemicals of abiological or biological origin that aid in the blood clotting process.

Methods for making a multicomponent hemostatic  dressing

A cellulose/silica composite useful as a filter material is highly selective towards a solute that has been molecularly imprinted upon an inorganic gel coating formed on the cellulose. The filter material provides dual filtering functionality, as both a selective molecular sieve and as a particulate filter. A unique method for making the filter material is also set forth that imparts these attributes and performance capabilities.

Molecular imprinting of solute on cellulose/silica composite, and products and uses thereof

Stable cellulosic fiber material for use in forming zeolite/cellulose composites is prepared by suspending loose cellulose fibers in an aqueous solution of sodium hydroxide, potassium hydroxide or sodium silicate, stirring the resulting suspension until it reaches a macroscopically homogenous appearance, heating the resulting mixture at a temperature of 323-423 K until only dry solids remain, contacting the resulting mixture with excess distilled water to remove physically adsorbed or trapped sodium hydroxide, potassium hydroxide or sodium silicate from the fibers, and heating the resulting fiber material at 323-423 K to dry the fiber material. Stable zeolite/cellulose composite material characterized in that leaching of the zeolite phase does not occur upon contact of the composite with water at approximately 373 K comprises a zeolite and a stable cellulosic fiber prepared as described above, the composite material being formed by contacting a zeolite with the stable fiber material.

Growing community of inventors

Lincoln, NE, United States of America

Gustavo Larsen