University of Washington

Yeda Research and Develpment & Co. Ltd

Gustav Oberdorfer

David Baker

Dan S Tawfik

Sarel Fleishman

Lauren Carter

Yaacov Ashani

Sagar D Khare

Adi Goldenzweig

Moshe Goldsmith

Lucas Nivon

Izhack Cherny

Nidhi Aggarwal

Enrique Marcos

Haim Leader

Per Jr Greisen

Tamuka Chidyausiku

Beta-sheet forming polypeptides at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-24 are disclosed, together with their use and methods for designing beta-sheet forming polypeptides.

De novo designed non-local beta sheet proteins

A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.

Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage

Growing community of inventors

Seattle, WA, United States of America

Gustav Oberdorfer