Yale University

Invitrogen Corporation

Pangene Corporation

Gurucharan Reddy

Charles Meyer Radding

Efim Ilya Golub

David C Ward

David A Zarling

Thomas Haaf

Hong Zeng

Boris Belotserkovskii

Anne Vallerga

The invention relates to methods for inhibiting, cloning, modifying or labelling an endogenous DNA sequence using compositions comprising recombinases in combination with exogenous polynucleotides containing 'anchoring' or 'locking' sequences. The anchoring sequences serve to stabilize structures formed by the exogenous polynucleotides and the endogenous DNA. The stabilized structure thus can either serve to regulate gene transcription or replication, or can allow the endogenous sequences to be labelled or pulled out, i.e. cloned, or modified.

Locked nucleic acid hybrids and methods of use

Provided herein are methods for inhibiting cell proliferation in an individual comprising administering to the individual a composition comprising a Rad51 inhibitor. Also provided herein is a method for inhibiting the growth of a cell comprising administering to said cell a composition comprising a Rad51 inhibitor. Such methods can further include the step of providing radiation or DNA damaging agents after administration of said Rad51 inhibitor. Also described herein are methods which are performed in vivo and/or on cancerous cells.

Antisense inhibition of RAD51

Compositions and methods are provided for identifying and diagnosing individuals at risk for a disease state associated with aberrant Rad41 foci.

Methods and compositions utilizing Rad51

Compositions and methods are provided for identifying agents which bind to or modulate Rad51.

The invention relates to complexes of eukaryotic Rad52 protein and nucleic acids, and methods of using the complexes.

Growing community of inventors

Redwood City, CA, United States of America

Gurucharan Reddy