The United States of America, As Represented by the Secretary, Department of Health and Human Services

Gurmeet Kaur

Edward A Sausville

Venkatachala L Narayanan

Ravi K Varma

Disubstituted lavendustin A analogs that are PTK inhibitors having antiproliferative activity are described. Preferred compounds of the disclosure, without limitation, satisfy either Formula 1 or Formula 2.The present disclosure also provides pharmaceutical compositions comprising effective amounts of disubstituted lavendustin A analogs and potentially comprising other active ingredients, other materials conventionally used in the formulation of pharmaceutical compositions, and mixtures thereof. The compounds and compositions of the disclosure can be used for treating subjects to, for example, inhibit the proliferation of living cells in the treatment of proliferative diseases.

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Germantown, MD, United States of America

Gurmeet Kaur