Council of Scientific and Industrial Research

Gurdarshan Singh

Jhillu Singh Yadav

Ghulam Nabi Qazi

Santu Bandyopadhyay

Naresh Kumar Satti

Krishan Avtar Suri

Om Parkash Suri

Kasturi Lal Bedi

Rakesh Kamal Johri

Bal Krishan Chandan

Subhash Chander Sharma

Siddhartha Roy

Bishan Datt Gupta

Bupinder Singh Jaggi

Aditya Konar

Bal Krishan Kapahi

Balram Ghosh

Radha Krishna Palakodety

Arun Bandyopadhyay

Bholanath Paul

Neelam Sharma

Mabalirajan Ulaganathan

Vasanta Madhava Sharma Gangavaram

Dipak Kar

Tanima Banerjee

Debaprasad Jana

Sibabrata Mukhopadhyay

Mumu Chakraborty

Musarat Amina

Tulika Mukherjee

The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients. Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below:  Herbal route for the isolation of compound of general formula 1 from the bark of plantand chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

Method for treatment of bronchial asthma

A process of isolation of pure Acteoside of high hepatoprotection from plant, said process comprising steps of drying aerial parts of the plant, grounding the dried parts into powder, percolating the powder with water or ethanol for 3-4 times to obtain an extract, filtering the extract for clearing of suspended particles to obtain supernatant, drying the supernatant at about 45 to 55&#xb0; C. to obtain a residue, fractionating the residue with chloroform, ethyl acetate, and butanol successively, subjecting butanol fraction to adsorption chromatography of SiOafter adding methanol to the fraction, charging the adsorbed fraction to glass column, eluting the column with solvents of increasing polarity of methanol:chloroform to obtain further fractions and repeating the process one more time, subjecting the fractions to column chromatography to obtain fractions, concentrating the fractions under reduced pressure to obtain acteoside as residue; and a method of effectively hepatoprotecting a subject using pure Acteoside from plant, said method comprising steps of administering appropriate low-dose of the acteoside to the subject.

Hepatoprotective agent of plant origin and a process thereof

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Jammu, India

Gurdarshan Singh