Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Guozhi Tang

Xianfeng Lin

Jason Christopher Wong

Zongxing Qiu

Lisha Wang

Weixing Zhang

Lei Guo

Guolong Wu

Haixia Liu

Patrizio Mattei

Wei Zhu

Daniel Hunziker

Chungen Liang

Harald Mauser

Jerome Hert

Xihan Wu

Zhenshan Zhang

Hong Shen

Alexander Mayweg

Taishan Hu

Mingwei Zhou

Buelent Kocer

Shixiang Yan

Yimin Hu

Isabel Najera

Zhanguo Wang

Jérôme Hert

John G Cumming

Virginie Sandrin

Hong Sheng

Alexander V Mayweg

The invention provides novel compounds having the general formula (I) wherein R, Y, A, W, R, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.

Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors

Bicyclic derivatives

The present invention relates to compounds of formula (I): 

Pyridazinone-based broad spectrum anti-influenza inhibitors

The invention provides novel compounds having the general formula: wherein R, R, R, R, R, M and X are as described herein, compositions including the compounds and methods of using the compounds.

4-methyl-dihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection

The invention provides novel compounds having the general formula: wherein R, R, R, Rand A are as described herein, compositions including the compounds and methods of using the compounds.

6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein Rto Rand X have the significances given herein. The present invention is also directed to processes for making said compounds and uses of said compounds, in particular their use as medicaments, more particularly their use as medicaments in the treatment of cancer.

N-hydroxy-benzamids for the treatment of cancer

The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein Rto R, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.

4-amino-N-hydroxy-benzamides for the treatment of cancer

The present invention is directed to a compound of formula I, and processes for the manufacture of said compounds as well as medicaments containing said compound. The compounds according to this invention show anti-proliferative and differentiation-inducing activity and are thus useful for the treatment of diseases such as cancer in humans or animals.

Ortho-aminoanilides for the treatment of cancer

Compounds of formula are HDAC inhibitors. These compounds are useful for the treatment of diseases such as cancer in humans or animals.

Ortho aminoamides for the treatment of cancer

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Shanghai, China

Guozhi Tang