Sichuan Kelun-biotech Biopharmaceutical Co., Ltd.

Hitgen, Inc.

Chengdu Sintanovo Biotechnology Co., Ltd.

Guoqing Zhong

Jingyi Wang

Lichun Wang

Hongmei Song

Qiang Tian

Jiaqiang Cai

Shuai Song

Tongtong Xue

Hong Zeng

Liang Xiao

Hanwen Deng

Haitao Huang

Jing Wang

Dengnian Liu

Jin Li

Mingliang Zhao

Qiang Zhang

Wei Zhong

Yao Liu

Jinqiao Wan

Dengfeng Dou

Yan Zhang

Fei Pan

Xi Hu

Jian Gao

Jingchao Feng

Zujian Tang

Rongrong Long

Yuting Tan

Xin Zhou

Liping Liu

Xing Wang

Xiao Hu

Yitao Zhang

Hai Hu

Yuanbo Li

Sijun Li

Xiaoping Fu

Haibo Zhou

Yu Yuan

Ruibin Hu

Xiaohu Ge

Benyanzi Yang

Peng Lv

Yongjia Hao

Yun Mu

Shaojun Liu

Caikui Li

Provided herein are bioactive molecule conjugates, preparation methods and use thereof, particularly bioactive molecule conjugates (such as antibody-drug conjugates and small molecule drug conjugates) obtained by improved coupling of a drug and a targeting moiety, as well as their preparation method and use for the treatment of a disease associated with an abnormal cell activity.

Bioactive molecule conjugate, preparation method and use thereof

The present invention discloses a polypeptide compound, a pharmaceutical composition, and a preparation method and use thereof. The structural formula of the polypeptide compound is shown in general formula (I):  Such polypeptide compounds as &#x3ba;-opioid receptor agonists have the advantages of better activity and the potential to become clinical candidate compounds.

Polypeptide compound, pharmaceutical composition, preparation method and application thereof

Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3&#x3b6; molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.

Cytotoxin and conjugate, uses of same and preparation method therefor

Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.

Nucleoside phosphate compound and preparation method and use thereof

The present invention discloses a method for capturing drug targets, comprising the following steps of: (1) preparing row materials, i.e., compounds and DNA or RNA or one party of other specific affinity materials; (2) linking: covalently linking the compounds to the DNA or RNA or the one party of other specific affinity materials, to obtain labeled compounds; (3) transferring: transferring the labeled compounds obtained in the step (2) into cells by a specific gene transfer method; (4) capturing targets: disrupting the cells in the step (3), and then capturing the DNA or RNA in the step (1) by immobilized complementary DNA or RNA, or capturing the one party of affinity materials in the step (1) by the other party of immobilized specific affinity materials, thus to enrich the targets through the covalently linked labeled compounds and the affinity of the targets; (5) identifying targets: dissociating the enriched targets from a stationary phase, deploying the targets by a gel electrophoresis method or by an equivalent separation method, and comparing differential proteins by proteomics thus to identify the potential targets; and (6) determining targets: expressing or purchasing the targets identified in the step (5) by priority, and comparing by interaction of the compounds with those targets one by one to determine the targets for the compounds. By the method of the present invention, compounds with low membrane permeability may be transferred into cells to be bound with the targets in the cells, to realize the target identification closer to the real physiological environment and thus provide more conclusive evidences for the acting mechanism of the compounds to diseases. Additionally, the method for capturing drug targets of the present invention is novel, easy, efficient, and low in cost, and has good application prospects.

Drug target capturing method

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Chengdu, China

Guoqing Zhong