Shanghai Hutchison Pharmaceuticals Limited

Chinese Academy of Sciences

Guoqiang Lin

Junjie Zhou

Ping Tian

Changsen Zhan

Jiange Zhang

Wenwen Xu

Jin Ren

Zhengguang Zhang

Chunxiao Cui

Jianguang Lei

Chenguo Feng

Minghua Xu

Preparation method of glycoside compounds is involved in the invention, with the advantages of short synthesis steps, high stereoselectivity and yield, simple production operation, low equipment requirements, environmental protection and suitability for industrial mass production.

Preparation method of a glycoside compound

The present invention discloses a glycoside compound represented by Formula III, and a preparation method, a composition, use and an intermediate thereof. The glycoside compound provided in the present invention has simple preparation method, can significantly increase the expression of VEGF-A mRNA, and is effective in promoting the angiogenesis. This provides a reliable guarantee for the development of drugs with pro-angiogenic activity for treating cerebral infarction cerebral stroke, myocardial infarction, and ischemic microcirculatory disturbance of lower limbs.

Glycoside compound and preparation method therefor, composition, application, and intermediate

4-Substituted coumarin compounds having the general formula of where R is H, CHO, OCH, X, NO, an alkyl having C, &#x2014;OCHO&#x2014;, an aryl being mono- or poly-substituted with CN or COOCHwith the aryl being a phenyl, naphthyl, or azaryl, or a coumarin group that is substituted with R, R, R, R, with R, R, R, and Rbeing H, an alkyl having C, X, NO, CN, OCH, COOCHor OR, Rbeing H or an alkyl having C, and X being a halogen.

Coumarin compounds and method for preparing and using the same

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Shanghai, China

Guoqiang Lin