Baoshan Iron & Steel Co., Ltd.

Medshine Discovery Inc.

Antengene Discovery Limited

Guoqiang Dai

Shuhui Chen

Jian Li

Ming Zhang

Wenyuan Qian

Chundao Yang

Ruimin Wu

Saidan Yang

Junliang Qiao

Chengguo Jin

Shengbo Pan

Bing Hou

Qian Xiang

Bin Jiang

Jay Mei

Ya Kong

Yulong He

Lulu Jiang

The present application provides novel PRMT5 and/or MTA-cooperative PRMT5 inhibiting compounds, or pharmaceutically acceptable salts thereof. The present application also provides pharmaceutical compositions comprising one or more of the compounds, or pharmaceutically acceptable salts thereof as an active ingredient, and the use of the compounds, or pharmaceutically acceptable salts thereof in the treatment of diseases or disorders, including cancers.

PRMT5 inhibiting compounds and uses thereof

Disclosed are a series of quinolino-pyrrolidin-2-one compounds, and application thereof in preparation of drugs for ATM inhibitor-related diseases. The present disclosure specifically relates to a derivative compound represented by formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof. 

Quinolino-pyrrolidin-2-one derivative and application thereof

An uncoiling, blanking and forming method includes the steps of: 1) uncoiling a steel coil, wherein a steel strip uncoiled from the steel coil is cleaned and straightened and is fed by a pinch roller to a blanking region; 2) laser blanking, wherein the steel coil enters the blanking region, is cut by a laser cutting head by way of laser blanking to form sheets with a required shape, with waste materials falling down and being conveyed to the outside; 3) outputting the sheets, wherein the sheets pass over a magnetic telescopic belt conveyor, and then carried by means of a manipulator or a robot to a stamping process; 4) stamping forming, wherein the sheets are stamped to form workpieces; and 5) checking, wherein the workpieces are checked and put in storage. The present invention can achieve joining-up in series of a blanking line and a stamping forming line and realize matching therebetween, and can reduce intermediate steps such as stacking, packing, transportation, positioning, unpacking, carrying, and centring of sheets and stamping-formed workpieces, and also can reduce the room required for transfer, simplify the work flow and joins up procedures in series, to directly machine a material coil by laser blanking to form formed parts.

Uncoiling, blanking and forming method

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Shanghai, China

Guoqiang Dai