Chinese Academy of Sciences

Chinese National Human Genome Center at Shanghai

Guoping Zhao

Xiangyin Kong

Jun Xu

Rui Xu

Landian Hu

Liandian Hu

Jinlin Hou

Jun Min

Shunsheng Yan

Shangxi Xiao

Chuan Yu

Meilei Jin

Xinwei Wu

Yixue Li

Yiping Jin

Lei Bu

Changchun Tu

Yerjiang Sulitang

Huai-Dong Song

The method of diagnosing lesions of crystalline lens such as cataract is disclosed. It comprises detecting variation of crygs gene, transcript and/or protein of individuals compared with normalty. The individual suffers from cataract more possible than normalty when occurring the variation. The present invention also discloses the method and pharmaceutical composition of treating lesions of crystalline lens such as cataract.

Method of diagnosing and treating lesion of crystalline lens using human CRYGS gene and coding product thereof

The invention has disclosed a method for diagnosis of dentinogenesis imperfecta type II (DGI-II) and/or dentinogenesis imperfecta type II with deafness (DGI-II with deafness). Said method comprises the steps of detecting the DSPP gene, transcript and/or protein in said subject and comparing it with the normal DSPP gene, transcript and/or protein to determine whether there is any variation, wherein said variation indicates that the possibility of suffering DGI-II and/or DGI-II with deafness in said subject is higher than the normal population. The present invention also discloses the method and pharmaceutical composition for treating DGI-II and/or DGI-II with deafness.

Method of diagnosing and treating dentinogenesis imperfecta type II by using dentin sialophosphoprotein gene and coded product thereof

Severe Acute Respiratory Syndrome ('SARS') is a human respiratory disease of recent origin, widespread infectivity, recurring incidence, and significant mortality. Although there is abundant evidence suggesting that the coronavirus responsible for the disease ('SARS-CoV') evolves during an outbreak, there is currently little data on the earliest strains of this coronavirus. The present invention is directed to the characterization of the genomic RNA sequences of these earliest SARS coronaviruses, to the identification of nucleotide positions within the SARS-CoV genomic RNA that are characteristic of the different evolutionary stages of the coronavirus, to kits based on these positions for use in diagnosis of the disease in patients, and for the development of vaccines to the disease based on the lowered virulence and contagiousness of these earliest strains of SARS-CoV.

Characterization of the earliest stages of the severe acute respiratory syndrome (SARS) virus and uses thereof

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Shanghai, China

Guoping Zhao