Zhejiang Hisun Pharmaceutical Co., Ltd.

Shanghai Aryl Pharmtech Co., Ltd.

Guoping Jiang

Taishan Hu

Lei Chen

Cheng Ye

Yanghui Guo

Liang Gong

Lichen Meng

Wentao Mao

Xiangui Huang

Youxi Chen

Qing Xiang

Weiwei Liao

Xingwu Zhu

Provided are a macrolide derivative represented by formula (I), a preparation method thereof, and an application of the macrolide derivative as an inhibitor of one or more protein kinases of TRK, ALK and ROS1,

Macrolide derivatives, preparation method and application thereof

Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (ATR) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description. 

Tetrahydroisoquinoline derivative, preparation method therefor and use thereof

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Guoping Jiang