Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Beijing Molecule Science and Technology Co., Ltd.

Peking University

Institute of Pharmacology and Toxicology Academy of Military Medical Science P.l.a. China

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.l.a. China of Beijing

Hunan Nanxin Pharmaceutical Co., Ltd.

Guoming Zhao

Song Li

Zhibing Zheng

Lili Wang

Wu Zhong

Junhai Xiao

Xinbo Zhou

Xingzhou Li

Yunde Xie

Xiaokui Wang

Hongying Liu

Xian Wei Zhang

Hongliang Wang

Wei Chen

Hao Cui

Xuejun Zhu

Zehui Gong

Mingming Zhao

Chunlai Mi

Guangqiang Xia

Ying Wang

Yang Zhang

Yao Liu

Jing Su

Jing Yan Ma

Ping Liu

Hui Qi

Dalong Ma

Jing Ma

Enquan Xu

Xiaoqian Xu

Hua Guan

Meina Li

Xiaomei Ling

Hongwei Gong

Xian Zhang

The invention relates to a compound of formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection. 

Bacterial quorum sensing regulator and medical use thereof

A derivative of homoserine lactone represented by formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection. 

Derivative of homoserine lactone, and preparation method and use thereof

Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, methods of treating and/or preventing diseases or disorders associated with viral infections in patients using the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by Formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification. 

Pyridazine derivatives and use thereof as medicaments for treating microRNA viral infection

The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.

(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof

Provided are piperazinyl pyrimidine derivatives of formula I having CCRantagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and prevention of CCR-related diseases. 

Piperazinyl pyrimidine derivatives, preparation method and use thereof

Disclosed is as a substituted thiazolamine derivative represented by Formula I or a pharmaceutically acceptable salt thereof or a hydrate thereof (the definitions of each group in the formula are as presented in the description), and the application thereof in the prevention and/or treatment of viral diseases induced by picornavirus. Also disclosed is a pharmaceutical composition containing the compound. 

Thiazolamine derivative and use thereof as anti-picornaviral infection medicament

(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-l-carboxylic acid hydrates pharmaceutical uses thereof

Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their isomers, pharmaceutically acceptable salts or hydrates are provided, wherein each variable has the meaning as defined in the description. Also provided are a process for preparing the compounds of the general formula (I), the use of the compounds, an isomer thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof as a medicament, in particular as a medicament for the treatment and/or prevention of Hepatitis B.

Dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof

Aromatic butan-2-ol compounds, preparation methods for making the compounds, and uses of the compounds are provided. Specifically, the compound of Formula I, or an optical isomer, racemate, diastereomer, pharmaceutically acceptable salt, or solvate thereof, is provided, where each of the substituents is defined. In addition, a pharmaceutical composition containing the compound, and the use of the compound in manufacture of a medicament for the treatment and/or prophylaxis of a disease or disorder caused byinfection, is provided. 

Aromatic butan-2-ol compounds and preparation and uses thereof

The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.

Arene connected polyamine macrocyclic derivatives, preparation methods and pharmaceutical uses thereof

The present invention relates to substituted pyridazinylamine derivatives of the formula I or pharmaceutically acceptable salts or hydrates thereof, wherein the substituents are defined as in the description, their preparation process, pharmaceutical compositions comprising them, and uses of the said compounds as picorna virus inhibitors for prevention and/or treatment of diseases caused by picorna viruses. 

Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors

The present invention relates to an optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing the optically pure compound of formula (I), and use of the optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis. 

Optically pure dihydropyrimidine compounds and their uses for the preparation of a medicament for treatment and prevention of viral diseases

The present invention relates to a compound of formula (I) or isomers thereof, or pharmaceutically acceptable salts or hydrates thereof. The present invention further relates to processes for the preparation of the compounds of formula (I) and optical isomers, and to the use of the compounds of formula (I), or isomers thereof, or pharmaceutically acceptable salts or hydrates thereof as medicaments, in particular as medicaments for the treatment and prevention of Hepatitis B. 

Tetrahydroquinazoline compounds and their use in preparing medicaments for treating and preventing virosis

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis. 

Dihydropyrimidine compounds and their uses in preparation of medicaments for treating and preventing antiviral diseases

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Beijing, China

Guoming Zhao