Hoffmann-la Roche Inc.

Coval Biopharma (shanghai) Co., Ltd.

F. Hoffmann-la Roche Ag

Guolong Wu

Mingwei Zhou

Haixia Liu

Lichun Feng

Wei Zhu

Lei Guo

Xianfeng Lin

Mengwei Huang

Hongying Yun

Yongfu Liu

Li Chen

Hong Shen

Weixing Zhang

Taishan Hu

Lisha Wang

Alexander Mayweg

Fabian Dey

Buelent Kocer

Guozhi Tang

Yimin Hu

Zongxing Qiu

Song Feng

Zhisen Zhang

Jim Zhen Wu

Buyu Kou

Shixiang Yan

Houguang Shi

Gangqin Li

Chungen Liang

Chao Li

Xiufang Zheng

Lu Gao

Dongdong Chen

Hao Zhang

Isabel Najera

Yongguo Li

Baoxia Wang

Dafeng Li

Hong Sheng

Weijiang Zhang

John G Cumming

Virginie Sandrin

Alexander V Mayweg

An anti-inflammatory drug compound, and a preparation method therefor and the use thereof. The structural formula of the compound is A-Y—B, wherein A is a group after dehydrogenation of an amine compound having JAK inhibitory activity, Y is a direct connection or —(CH2)-O— or, and B is a group formed by means of dehydroxylation of a carboxy-containing carboxylic acid compound B1, or a group formed by means of dehydrogenation of a hydroxy-containing compound B2. The compound has the special effects of having a strong transdermal property, controlled drug release, high efficacy, etc.

Anti-inflammatory coupling compound drug, and preparation method therefor and use thereof

The present invention relates to compounds of formula (I): 

Pyridazinone-based broad spectrum anti-influenza inhibitors

The invention provides novel compounds having the general formula: wherein R, R, R, R, R, R, W, W, W, A and X are as described herein, compositions including the compounds and methods of using the compounds for the treatment and prophylaxis of respiratory syncytial virus infection.

Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection

The present invention relates to compounds of formula (I), wherein R, Rand Rare as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection

The present invention relates to compounds of formula (I), wherein R, R, R, R, Rand Rare as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Compounds for the treatment of infectious diseases

The invention provides novel compounds having the general formula: wherein R, R, R, R, R, M and X are as described herein, compositions including the compounds and methods of using the compounds.

4-methyl-dihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection

The invention provides novel compounds having the general formula: wherein R, R, Rand Rare as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.

6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula: wherein R, R, R, Rand A are as described herein, compositions including the compounds and methods of using the compounds.

6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein Rto R, Ato Ahave the are as described herein and compositions including the compounds.

Tetrahydroquinoline derivatives

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein Rto Rhave the significance given in claim, can be used as a medicament.

3,3-dimethyl tetrahydroquinoline derivatives

The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein Rto Rhave the significance given herein. The compounds are activators of AMP-activated protein kinase (AMPK) and are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.

The invention provides novel compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Rto Rare as described herein, compositions including the compounds and methods of preparing and using the compounds.

Isoquinoline derivatives

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Shanghai, China

Guolong Wu