Medshine Discovery Inc.

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Guoli Zhang

Shuhui Chen

Yunfu Luo

Maoyi Lei

Yu Xu

Jian Li

Yong Wang

Shaolong Li

Jinghong Dong

Junmiao Li

Sheng Su

Jianfeng Pan

Weizhi Ge

Provided is a fused tri-cyclic compound as PDE3/PDE4 dual inhibitor, and a use thereof in the preparation of drugs for PDE3/PDE4 associated diseases, particularly in medicinal functions such as chronic obstructive pulmonary disease (COPD). Provided are specifically a compound of formula (I) and a pharmaceutically acceptable salt thereof.

Fused tri-cyclic compound as PDE3/PDE4 dual inhibitor

A compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and disclosed is an application thereof in the preparation of a medication for treating diseases related to a CRBN receptor.

Bicyclic compound that acts as CRBN protein regulator

Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof. 

Tricyclic furan-substituted piperidinedione compound

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Shanghai, China

Guoli Zhang