Baxter International Inc.

Baxter Healthcare Sa

Other

Bayer Corporation

Siemens Healthcare Diagnostics Gmbh

Siemens Medical Solutions Diagnostic

Baxalta Gmbh

Guohan Yang

Say-Jong Law

Todd B Sells

Larry Richard Brown

Ton That Hai

Anand Natrajan

Qingping Jiang

David J Sharpe

Paul Jeffrey Sanders

Cong Jiang

Arounaguiry Ambroise

Hartmut Schroeder

Hana Lukinsky

Bennett Melnick

Jie Li

Catherine Quinn

John E Monahan

Donna M Ford

The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

Polymeric benzyl carbonate-derivatives

This invention is a method of using a class of excipients for protein formulation to reduce and/or eliminate protein aggregation in solutions or solids. This class of compounds contains carbonyl group(s) to form Schiff base(s) with amino groups of proteins and also contains moieties to keep protein molecules spatially separated. This method has never been disclosed anywhere in the literature.

Excipients for protein stabilization

Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base formation, or acridinium sulfonamides with or without electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus.

Applications of acridinium compounds and derivatives in homogeneous assays

Highly hydrophilic non-nucleosidic tags with multiple labels are provided for use in nucleic acid probes. The tags are branched structures having a phosphodiester backbone, which have the advantages of a small dimensional size and high hydrophilicity. After the tag is labeled, its high negative charge and minimal size help to keep the carriers away from DNA or RNA molecules, due to repulsion between negative charges. Non-specific intercalation and steric hindrance are therefore minimized, and the hydrophobicity, if any of reporter molecules is reduced. The probes are used in place of conventionally labeled oligonucleotides for a variety of hybridization reactions.

Nucleic acid probes having highly hydrophilic non-nucleosidic tags with multiple labels, and uses thereof

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Mansfield, MA, United States of America

Guohan Yang