Gilead Sciences, Inc.

Guofeng Cheng

William E Delaney, Iv

Hongmei Mo

Mei Yu

Simin Xu

Betty Peng

Amoreena Corsa

Replicons of genotype 6 hepatitis C virus (HCV) are provided. These replicons contain adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 6 replicons and methods of using these replicons to screen antiviral agents are also provided.

HCV genotype 6 replicons

Replicons of genotype 3 of hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 3 replicons and methods of using these replicons to screen antiviral agents are also provided.

HCV genotype 3 replicons

Replicons of genotype 4 hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 4 replicons and methods of using these replicons to screen antiviral agents are also provided.

Growing community of inventors

Foster City, CA, United States of America

Guofeng Cheng