F. Hoffmann-la Roche Ag

Centrillion Technology Holdings Corporation

Leland Stanford Junior University

University of Illinois

Roche Palo Alto LLC

Idbydna Inc.

Guochun Liao

Gary A Peltz

Rui Mei

Wei Zhou

Julian Lucas

Ming Zheng

Hajime Matsuzaki

Filip Crnogorac

Timothy Alan Garrow

Jonathan A Usuka

Peng Lu

John David Allard

Dee Aud

Hong-Hsing Liu

Dee Marie Aud

Yuying Mei

Gary Allen Peltz

The present invention provides methods and systems for sequencing long nucleic acid fragments. In one aspect of the invention, methods, systems and reagent kits are provided for sequencing nucleic acid target sequences. Some embodiments of the methods, systems and reagent kits are particularly suitable for sequencing a large number of fragments, particularly long fragments.

Methods and systems for sequencing long nucleic acids

The present invention provides methods and systems for sequencing long nucleic acid fragments.

The present disclosure relates generally to a pharmaceutical compositions and methods of reducing acetaminophen-induced liver toxicity. The disclosure includes pharmaceutical compositions including acetaminophen and one or more components selected from S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof. The disclosure also relates to methods of reducing acetaminophen-induced liver toxicity in a subject by administering or co-administering one or more of S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof, with acetaminophen to a subject.

Compositions and methods for reducing the risk of agent-induced liver toxicity

Systems and methods for aligning objects in object sets are provided. An object set has objects that are in a corresponding image in a plurality of images. For each respective object in a first object set, a corresponding object group is constructed that contains the respective object, thereby constructing a plurality of object groups. Similarity metrics are computed between object groups and objects in objects sets in order to assign the objects to object groups. The object groups are then refined in order to align objects in the object sets.

Systems and methods for alignment of objects in images

Methods and reagents for determining the genotoxicity of a compound based on genomic responses to contact therewith are provided.

Method for determining genotoxicity

Computer systems, computer program products and methods for processing an input nucleic acid chromatogram having a plurality of substantially simultaneous traces. Each trace in the plurality of traces has a plurality of datapoints. Each respective datapoint in each of the plurality of datapoints represents a signal amplitude at a position in the trace corresponding to the respective datapoint. A first peak is identified in a first trace that is substantially overlapping a second peak in a second trace in the plurality of traces. The first peak is outputted to a first output homozygous representation and the second peak is outputted to a second output homozygous representation. The first output homozygous representation is a first homozygous sequence representation or a first homozygous nucleic acid chromatogram corresponding to the input nucleic acid chromatogram. The second output homozygous representation is a second homozygous sequence representation or second homozygous nucleic acid chromatogram of the input nucleic acid chromatogram.

Systems and methods for processing nucleic acid chromatograms

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Belmont, CA, United States of America

Guochun Liao