Philera New Zealand Limited

Actelion Pharmaceuticals Ltd

Ucb S.a.

Idorsia Pharmaceuticals Ltd

Protemix Corporation Limited

Gunther Schmidt

Irene Vaulont

Marco Jonas

Antonio Soi

Stefan Abele

Martin Bolli

Jacques-Alexis Funel

John Surtees

Guy Duchene

Didier Bouvy

Patric Dörrwächter

Hans Meier

Heinz Steiner

Antoine Thomas

Yves Combret

Michael Frank

Jean-Philippe Surivet

Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

Synthesis of triethylenetetramines

The present invention relates to a process for the preparation of particular 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (I) to certain crystalline forms of potassium salts of said 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (I), to certain crystalline forms of said 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (I), and to their use in the preparation of pharmaceuticals such as (S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)-(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone.

Preparation of 2-([1,2,3]triazol-2-yl)-benzoic acid derivatives

The invention relates to a new process suitable for manufacturing the compounds of formula I (I) wherein W is H, Br, Cl or methyl, which are synthetic intermediates useful in the preparation of antibiotic compounds.

Process for manufacturing naphthyridine derivatives

The invention relates to a process and synthetic intermediates that can be used for manufacturing the compound of formula (1-6) which is a synthetic intermediate useful in the preparation of antibiotic compounds. 

Process for manufacturing a naphthyridine derivative

The present invention relates to a new process for the preparation of 2-imino-thiazolidin-4-one compounds of the Formula (I) and (II) and to compounds of Formula (II) as such. The present compounds of Formula (II) can be used as intermediates in the preparation of thiazolidin-4-one derivatives of the General Formula (II), said derivatives being described in WO 2005/054215. These compounds of General Formula (II) are described in WO 2005/054215 to act as immunosuppressive agents.

Process for the preparation of 2-imino-thiazolidin-4-one derivatives

The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I)  Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.

Process for the preparation of 2-oxo-1-pyrrolidine derivatives

The present invention relates to a new process for the preparation of 2-imino-thiazolidin-4-one compounds of the Formula (I) and (II) and to compounds of Formula (II) as such. The present compounds of Formula (II) can be used as intermediates in the preparation of thiazolidin-4-one derivatives of the General Formula (II), which thiazolidin-4-one derivatives being described in WO 2005/054215 to act as immunosuppressive agents.

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Aarau, Switzerland

Gunther Schmidt