Bayer Aktiengesellschaft

Gunther Kinast

Andreas Knorr

Michael Schedel

Karl G Metzger

Johannes-Peter Stasch

Hans-Joachim Zeiler

Rolf Angerbauer

Walter Puls

Wolfgang Bender

Lutz Muller

Rudiger Sitt

Michael Boberg

Matthias Schuller

Stanislav Kazda

Bodo Junge

Jurgen Stoltefuss

Horst Boshagen

Wilfried Schrock

Arnold Paessens

Michael Kayser

Eckhard Schwenner

Theo Schroder

Wolfgang Koebernick

Renin-inhibiting peptides of the formula ##STR1## in which X represents a group of the formula ##STR2## represents hydroxyl, alkoxy having up to 8 carbon atoms, benzyloxy or a group of the formula --NR.sup.4 R.sup.5,

Renin inhibitors

Renin inhibitors having all retro-inverted peptide bonds

A method for treating a viral infection in a human or animal patient comprising administering to such patient an antivirally effective amount of a substituted hydroxypiperidine, namely a 2-hydroxymethylene-3,4,5-trihydroxypiperidine.

Methods for treating viruses in patients by administering

A 3-amino-4,5-dihydroxy-piperidine compound of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl having up to 8 carbon atoms, aralkyl having 7 to 14 carbon atoms, or represents a group of the formula ##STR2## R.sup.4 denotes straight-chain or branched alkyl having up to 8 carbon atoms, straight-chain or branched alkoxy having up to 8 carbon atoms, or aralkoxy having up to 10 carbon atoms, and

3-Amino-4,5-dihydroxypiperidines, process for their preparation and

Circulation active, e.g. antihypertensive novel methionine-substituted dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or a heterocyclic radical, or a physiologically acceptable salt thereof.

Circulation active methionine-substituted 1,4-dihydropyridines

A process for the preparation of a cephalosporin of the formula ##STR1## in which R.sup.1 is an aliphatic or cycloaliphatic radical with up to 6 carbon atoms, and

Preparation of cephalosporins

Novel antibacterially active cephalosporins of the formula ##STR1## in which R.sup.1 denotes hydrogen, optionally substituted alkyl, a substituted or unsubstituted phenyl ring, a polycyclic aromatic ring or an optionally substituted heterocyclic 5- or 6-member ring having 1-4 heteroatoms,

Cephalosporins

Highly active substantially pure Z-isomers of cephalosporins are produced by the following synthesis: ##STR1## in which R.sup.1, R.sup.4 and R.sup.5 ae various organic radicals,

Intermediate products for the preparation of Z-cephalosporins

Antibacterially active cephalosporins of the formula ##STR1## in which R.sup.1 denotes C.sub.1 -C.sub.6 -alkyl, phenyl or halogen-substituted phenyl, and

A process has been developed for the preparation of compounds of the formula ##STR1## wherein R is hydrogen or an optionally substituted alkyl radical, which comprises reacting glucose with a compound of the formula H.sub.2 N-R wherein R has the meaning given above to form a 1-amino-sorbitol of the formula ##STR2## wherein R has the meaning given above, reacting said 1-aminosorbitol with a compound providing a protective group which can be split off under acid conditions and is stable in the subsequent microbiological oxidation process, aerobically oxidizing the compound thus obtained microbiologically to give a protected 6-aminosorbose, splitting off the protective group under acid conditions and hydrogenating the 6-aminosorbose salt thus obtained either after being isolated or in one operation, to give the compound of the formula (I). The products obtained by the process of the invention are useful as .alpha.-glucoside inhibitors.

Production of N-substituted derivatives of 1-desoxynojirimicin

The invention relates to .alpha.-hydroxyalkyl-3,4,5-trihydroxypiperidines defined by Formula (I), infra, and pharmaceutical compositions and medicaments containing said compounds. Also included in the invention are methods for the use of said compounds, compositions and medicaments as inhibitors of .alpha.-glucoside hydrolases; and intermediates for the compounds of said Formula (I).

2-Hydroxyalkyl-3,4,5-trihydroxy-piperidine compounds, their production

The invention relates to N-amino-3,4,5-trihydroxypiperidines, methods for their production, compositions containing said compounds. Also included are methods for the use of said compounds and compositions.

N-Amino-3,4,5-trihydroxypiperidines, their production and their

The invention relates to a process for the production of compounds of the formula ##STR1## in which R is hydrogen or optionally substituted alkyl, alkenyl, aralkyl or aryl, by microbiological transformation of ##STR2## follow by catalytic hydrogenation. The compounds obtained are useful for the treatment of diabetes, hyperlipoproteinaemia and adiposity which comprises aerobically cultivates, in the presence of an assimilable source of carbon nitrogen, at a temperature of 20.degree. to 45.degree. C. and pH between 2 and 10 and in the presence of an effective amount of a compound of the formula ##STR3## in which R has the above-given meaning and,

Production of N-substituted derivatives of 1-desoxy-nojirimycin

The invention relates to a process for the production of 6-amino-6-deoxy-L-sorbose which comprises culturing an aerobic micro-organism capable of oxidizing 1-amino-1-deoxy-D-glucitol or an enzymatic extract obtained from said aerobic micro-organism under aerobic conditions and at a suitable temperature in an aqueous nutrient medium containing 1-amino-1-deoxy-D-glucitol or a salt thereof and also containing assimilable sources of carbon, nitrogen and essential trace element to impart said 6-amino-6-deoxy-L-sorbose to said aqueous nutrient medium.

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Wuppertal, Germany

Gunther Kinast