Hoechst Aktiengesellschaft

Ciba-geigy Corporation

Boehringer Ingelheim International Gmbh

Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Dr. Karl Thomae Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Dr. Karl Tomae Gmbh

Dr. Karl Thomae Gesellshaft MIT Beschrankter Haftung

Gunther Jung

Karl-Heinz Wiesmuller

Friedrich Gotz

Thomas Kupke

Jochen Knolle

Stephan Henke

Peter Swetly

Roland Kellner

Leander Lauffer

Cortina Kaletta

Jorg Metzger

Karl-Dieter Entian

Birgit Jordan

Hans Bruckner

Hans-Georg Rammensee

Ralf Rosenstein

Johannes Augustin

Norbert Schnell

Cora Klein

Germar Engelke

Bernd Wieland

Gerhard Bozler

Susanne Feiertag

Hans-Jorg Buhring

Kirsten Falk

Christoph Kempter

Claudius Rapp

Armin Kern

Hansjorg Schild

Martin Kugler

Karl Deres

Wolfgang Loeffler

Gerhard Becker

Stefan Stevanovic

Wolfgang Bessler

Olaf Rotzschke

The invention relates to compounds of the formula I

Cyclohexapeptides and their mixtures, a process for preparing them, and

According to certain embodiments, the invention relates to an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a protein of a virus, a bacterium, a parasite or a tumor antigen. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunogenic composition for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.

Membrane anchor/active compound conjugate, its preparation and its uses

According to certain embodiments, the invention relates to a method of producing antibodies employing an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a viral, bacterial, or protoral protein. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunoconjugate for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.

A method is described for oxidatively decarboxylating a peptide, comprising combining a peptide with EpiD, wherein the peptide comprises at its carboxy terminus the amino acid sequence X.sub.1 X.sub.2 X.sub.3 X.sub.4 X.sub.5 X.sub.6 C, wherein X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are any one of the twenty common amino acids, X.sub.5 is Tyr, Val, Met, Leu, Ile, Phe or Trp, and X.sub.6 is Cys, Ala, Ser, Val, or Thr, whereby the oxidative decarboxylation of the peptide occurs.

Oxidative decarboxylation of peptides catalyzed by flavoprotein EpiD

A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described. Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.

Biosynthetic process for the preparation of chemical compounds

A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described. Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.

DNA encoding and biosynthetic process for the preparation of chemical

Determination of peptide motifs on MHC molecules

N-Acyl-S-(2-hydroxyalkyl)cysteines, their preparation and their use as intermediates for the preparation of synthetic immunoadjuvants and synthetic vaccines. Compounds of the formula I ##STR1## in which the substances X, Y, R, R.sup.1 and R.sup.2 have the meanings mentioned, are suitable for the preparation of lipopeptides and lipoamino acids.

N-acyl-S-(2-hydroxyalkyl) cysteines, their preparation and their use as

Rhizocticines of the formula ##STR1## in which X represents hydrogen or a hydrophobic amino acid radical and Y represents a basic amino acid radical, the C2 atoms of the amino acid radicals having the L-configuration, and protected derivatives and salts thereof. The compounds are obtained from culture broths of Bacillus subtilis or synthetically and have especially fungicidal action.

Oligopeptide antibiotics

Tridecapeptide

Decapeptide

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Tubingen, Germany

Gunther Jung