Bausch-lomb Incorporated

Dr. Gerhard Mann Chem.-pharm. Fabrik Gmbh

Dr. Gerhard Mann Chemisch-pharmazeutische Fabrik Gmbh

Gunther Bellmann

Gudrun Claus-Herz

Cornelia Reimer Hevia

Christoph Kessler

The invention relates to a sterile ophthalmic drop preparation, especially a gel preparation, which comprises a two-phase carrier liquid or gel basis comprising a liquid aqueous and a liquid hydrophobic phase.

Sterile ophthalmological gel preparation applicable in drops and process for producing it

The invention relates to stable ophthalmic preparations including the penetrant antiphlogistic diclofenac or salts thereof and the penetrant antibiotic ofloxacin present in the form of the racemate, an enantiomer, particularly levofloxacin, or the corresponding hydrochloride thereof. The preparations may be used for treating eye infections and/or inflammations and for preventing infections before and after eye surgery.

Storage-stable ophthalmic compositions comprising diclofenac and ofloxacin

Ophthalmic composition with prolonged residence time on the eye, in particular in the form of a gel which can be administered as drops, of an ointment or the like, containing a free-flowing vehicle with increased viscosity and a preservative, and, where appropriate, one or more active ingredients and conventional additives such as tonicity agents, substances to adjust the pH etc. The preservative is essentially formed according to the invention by a benzyllauryldimethylammonium salt. The invention furthermore relates to the use of a benzyllauryldimethylammonium salt as preservative for producing ophthalmic compositions intended for repeated use over lengthy periods and/or formulated for a lengthy residence time on the eye after each use, whereby irritation and/or damage to the tissue of the eye are avoided.

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Berlin, Germany

Gunther Bellmann