Godecke Aktiengesellschaft

Warner-lambert Company

Gunter Wolf

Gerhard Satzinger

Johannes Hartenstein

Edgar Fritschi

Horst-Dietmar Tauschel

Manfred F Herrmann

Hubert G Barth

Jurgen Kleinschroth

Hartmut Osswald

Karl Mannhardt

Volker Ganser

Bernd Wagner

Ute Weiershausen

The present invention provides combination of materials for strengthening the antithrombotic action of acetylsalicylic acid. It covers a composition which contains diltiazem or a pharmaceutically acceptable acid-addition salt thereof in combination with acetylsalicylic acid. It also forms the new compound diltiazem acetysalicylate. It also covers compositions containing the above and methods for using the compositions or compound.

Pharmaceutical composition with antithrombotic activity

New 1,6-naphthyridinone derivatives of the formula I ##STR1## are herein described wherein R.sup.1 represents an unsubstituted or substituted aromatic or heteroaromatic ring;

Use of 1,6-naphthyridinone derivatives in treating pulmonary thrombosis

2-Alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles and pharmaceutically acceptable acid addition salts, processes for their preparation and formulation into pharmaceutical compositions as well as their activity as thrombocyte aggregation-inhibitors are described. The compounds are thus useful for the prophylaxis and therapy of thrombotic states.

2-Alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles, compositions and

Growing community of inventors

Freiburg, Germany

Gunter Wolf