Bayer Aktiengesellschaft

Gunter Thomas

Hilmar Bischoff

Peter Fey

Delf Schmidt

Walter Hubsch

Rolf Angerbauer

Dieter Petzinna

Thomas Philipps

For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl,

Disubstituted pyridines

Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings,

Substituted pyridines heptenoic acid derivatives, useful for treating

Substituted pyridyl-dihydroxy-heptenoic acid of the formula ##STR1## and its salts, if desired in an isomeric form, have a superior inhibitory action on HMG-CoA reductase and thus bring about a surprisingly good lowering of the cholesterol content in the blood.

Substituted pyridyl-dihydroxy-heptenoic acid and its salts

For the treatment of lipoproteinaemia and arteriosclerosis, the polysubstituted pridines of the formula ##STR1## in which R.sup.1 is optionally substituted furyl or thienyl,

7-[(2,6-dialkyl-4-furyl or

7-(polysubstituted pyridyl)-hept-6-endates useful for treating

For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula ##STR1## in which A is optionally substituted aryl or heterocyclic,

Substituted 2-pyridones and pyrid-2-thiones compounds

Substituted pyrido(2,3-d) pyrimidines of the formula: ##STR1## useful as intermediates for the preparation of MMG-CoA reductase inhibitors.

Substituted pyrido (2,3-d) pyrimidines as intermediates

New substituted pyrido(2,3-d)pyrimidines of the formula ##STR1## can be prepared by reduction of corresponding pyrido(2,3-d)-pyrimidines which are substituted by a ketone radical, and subsequent hydrolysis, cyclization or hydrogenation. The new compounds can be used to inhibit HMG-CoA reductase.

HMG-CoA reductase inhibiting substituted pryido (2,3-d) pyrimidines

Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and

Certain 7-[2,6-diisopropyl-4-phenyl-5-lower

For inhibiting 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase, the novel substituted pyrroles of the formula ##STR1## in which R.sup.1 is optionally alkyl or cycloalkyl,

Substituted pyrroles

Inhibiting HMG-CoA reductase, as in treating hyperlipopproteinaemia, lipoproteinaemia and arteriosclerosis, with the new N-substituted N-amino-pyrroles of the formula ##STR1## in which R.sup.1 is an organic radical,

HMG-CoA reductare-inhibiting N-substituted N-amino-pyrroles

HMG-CoA reductase-inhibiting compounds of the formula ##STR1## in which R.sup.1 is an optionally substituted alkyl as cycloalkyl radical,

Substituted imidazolinones and imidazolinethiones

For inhibiting 3-hydroxy-3-methylglutaryl coenzyme A and cholesterol biosynthesis, the novel disubstituted pyrroles of the formula ##STR1## in which R.sup.1 is aryl or heteroaryl,

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Arese, Italy

Gunter Thomas