Merck Patent Gesellschaft MIT Beschrankter Haftung

Celamerck Gmbh & Co. Kg

Gunter Lauterbach

Erich Schacht

Werner Mehrhof

Zdenek Simane

Herbert Nowak

Jurgen Curtze

Gerbert Linden

Klaus Thomas

Siegmund Lust

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, chlorine or fluorine; and

2-[4-(4-Chlorophenoxymethyl)-phenoxy]-propionic acid compounds as

Phenoxypropionic acid derivatives of the formula ##STR1## wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O--alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##STR2## with a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.

Phenoxypropionic acid derivatives and pharmaceutical preparations

Phenoxypropionic acid derivatives of the formula ##SPC1## Wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O-alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##SPC2## With a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.

Phenoxypropionic acid derivatives

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Darmstadt, Germany

Gunter Lauterbach