Viatris Gmbh & Co Kg

Meda Pharma Gmbh & Co. Kg

Gunter Laban

Wolfgang Sauer

Annegret Jannasch

Peter Meisel

Michael Müller

Gilbert Müller

The invention relates to a method for producing pure racemic, R- or S-thioctic acid or mixtures thereof by reacting 6,8-disubstituted octanoic acid or their salts or esters with sulfides, sulfur or sulfites.

Method for producing thioctic acid

The invention relates to a method for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of the general formula (R)-II or (S)-II in which R has the meaning C-alkyl, from 8-chloro-6-oxooctanoic acid alkyl esters of the general formula I in which R has the above meaning, by enzymatic reduction using alcohol dehydrogenases, such asor, in the presence of cofactor regeneration systems. The resulting (R)- and (S)-8-chloro-6-hydroxyoctanoic acid esters can be converted in a known manner into (R)-&#x3b1;-lipoic acid and (S)-&#x3b1;-lipoic acid, respectively.

Method for the production of (r)- and (S)-8-chloro-6-hydroxyoctanic acid alkyl esters by enzymatic reduction

The invention relates to new modifications of the trometamol salt of R-thioctic acid of the formula I,processes for their production, pharmaceutical preparations containing these modifications, and their medical application.

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Dresden-Langebrück, Germany

Gunter Laban