Degussa Aktiengesellschaft

Evonik Industries Ag

Ciba-geigy Corporation

Degussa - Huls Ag

Rohm Gesellschaft, Gmbh

Evonik Operations Gmbh

Gunter Knaup

Karlheinz Drauz

Milan Latinovic

Andreas Bommarius

Michael Karrenbauer

Friedhelm Merz

Thomas Gottstein

Stefan Retzow

Martin Bindl

Roland Herrmann

Christoph Weckbecker

Peter Ackermann

Hans-Peter Krimmer

Hanspeter Fischer

Michael Schwarm

Andreas Karau

Matthias Schafer

Elfriede Sextl

Ulrich Groeger

Ingo Klement

Hans-Albrecht Hasseberg

Stefan Stockhammer

Wiltrud Schafer-Treffenfeldt

Rolf Vogel

Hans-Jochen Hasselbach

Thomas Hermann

Jorg Lotz

The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a Dane salt according to formula II and a Dane salt according to formula III with a coupling reagent; b) adding a diamine according to formula IV to the reaction mixture; and c) adding an acid to the reaction mixture to adjust the pH value of the reaction to &#x3c;7; wherein L represents a C-Calkyl group, a C-Caryl group, or a C-Calkylaryl group; Rand Rcan be identical or different and represent a hydrogen atom, a C-Calkyl group, a C-Chydroxyalkyl group, a C-Cthioether group, a C-Caryl group, a C-Calkylaryl group, a C-Calkylhydroxyaryl group, a C-Calkylheteroaryl group with 1 to 4 heteroatoms; or a C-Calkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C-Calkyl group or a C-Calkylaryl group; Rrepresents a C-Calkyl group; Rrepresents a hydrogen atom, or a C-Calkyl group; Rrepresents a C-Calkyl group; and X represents an alkali metal.

Synthesis of diamido gellants by using Dane salts of amino acids

The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a N-carboxyanhydride according to formula II and a N-carboxy-anhydride according to formula III with a diamine according to formula IV and b) adding an acid to the reaction to adjust the pH value of the reaction to &#x3c;7; wherein L represents a C-Calkyl group, a C-Caryl group, or a C-Calkylaryl group; and Rand Rcan be identical or different and represent a hydrogen atom, a C-Calkyl group, a C-Chydroxyalkyl group, a C-Cthioether group, a C-Caryl group, a C-Calkylaryl group, a C-Calkylhydroxyaryl group, a C-Calkylheteroaryl group with 1 to 4 heteroatoms; or a C-Calkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C-Calkyl group or a C-Calkylaryl group.

Synthesis of diamido gellants by using amino acid N-carboxyanhydrides

The invention is directed to a process for the preparation of lactams of Formula I. It is further directed to new advantageous intermediates of Formula II and the use thereof. By the cyclization of compounds of Formula II, compounds of Formula I are obtained.

Procedure for the manufacture of 3-amino-2-oxo-pyrrolidines, new

The disclosure relates to a process for obtaining optically active L-.alpha.-aminocarboxylic acids from the corresponding racemic D,L,.alpha.-aminocarboxylic acids. The following steps are involved: (a) the D,L,.alpha.-aminocarboxylic acids are acetylated; (b) the N-acetyl-L-.alpha.-aminocarboxylic acid present in the mixture of N-acetyl-D,L,.alpha.-aminocarboxylic acids thus obtained is broken down enzymatically into the L-.alpha.-aminocarboxylic acid; (c) the L-.alpha.-aminocarboxylic acid is separated from the mixture, a quantity of a solution of N-acetyl-D(L)-.alpha.-aminocarboxylic acids and a quantity of acetate equivalent to the L-.alpha.-aminocarboxylic acid being retained; and (d) the N-acetyl-D(L)-.alpha.-aminocarboxylic acid is racemized and recycled for enzymatic breakdown. Known extraction processes involving steps (a) to (d) have the disadvantage of producing large quantities of salt. Specifically, the processes are far removed from the ideal equation, according to which one hundred percent of the acetic anhydride and the D,L,.alpha.-aminocarboxylic acids are converted to L-.alpha.-aminocarboxylic acids and acetic acid. Adjusting the retained solution from step (c) in such a way as to obtain a solution consisting essentially of N-acetyl-D-(L)-.alpha.-aminocarboxylic acid salt and free acetic acid in equilibrium with acetate and free N-acetyl-D(L)-.alpha.-aminocarboxylic acid and from which acetic acid is extracted by distillation makes it surprisingly easy to feed the solution formed as 'mother liquor' following separation of the L-.alpha.-aminocarboxylic acid in the circuit and to achieve a materials balance as close as possible to the ideal.

Process for obtaining active L-.alpha.-amino carboxylic acids from

With known methods of racemizing N-acetyl-D(L)-.alpha.-amino carboxylic acids in the non-aqueous state by heating them to temperatures above room temperatures, significant quantities of by-products are formed, especially acetyl dipeptides. By converting at least a proportion of the N-acetyl-D(L)-.alpha.-amino carboxylic acids to corresponding N-acetyl-D(L)-.alpha.-amino carboxylic acid salts before or during the heating, it is possible to increase the sojourn time of the educt which is to be racemized at higher temperatures without any evident increase in the quantity of by-product formed (in particular acetylated dipeptides). Also disclosed is the production of optically active amino acids by enzymatic splitting of racemic compounds.

Process for racemization of N-acetyl-(D)L-.alpha.-amino carboxylic acids

Method of producing oxazolidinones, the use thereof and novel

Method of producing L-aspartyl-D-alanine-N-(thiethane-3-yl)-amides

The invention relates to a process for removing amino acids and/or aminosulphonic acids from preferably aqueous solutions which contain these as impurities by adsorbing the amino acids on zeolites. Solutions to which the process according to the invention can be applied are produced, for example, from the industrial synthesis of oligopeptides in which the amino acids serving as starting materials are always present in solution, sometimes to a not inconsiderable residual concentration, together with the desired end product.

Process for separating amino acids and aminosulponic acids through

N-acyl dipeptides and their compositions

1-Aminocyclohexanecarboxylic acid derivatives of the formula I ##STR1## or their acid addition salts or a metal complex can be employed for protecting plants from microorganisms. In the formula I, R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, benzyl, or an ammonium radical which is unsubstituted or substituted by hydrocarbon radicals having not more than 20 C atoms, or a metal ion equivalent. Compounds of the formula I can be employed in the form of crop protection agents using suitable carrier materials.

Microbicidal compositions

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Bruchkobel, Germany

Gunter Knaup