Bayer Intellectual Property Gmbh

Bayer Cropscience Ag

Basf Se Corporation

Bayer Healthcare Aktiengesellschaft

Bayer Schering Pharma Ag

Gunter Karig

Mark James Ford

Konrad Siegel

Joachim Schuhmacher

Lars Bärfacker

Karl-Heinz Schlemmer

Andreas Knorr

Peter Kolkhof

Raimund Kast

Eva-Maria Becker

Jens-Kerim Ergüden

Joachim Hütter

Johannes-Peter Stasch

Rudolf Schohe-Loop

Thomas Lampe

Alexander Hillisch

Walter Hübsch

Kai Thede

Stefan Schnatterer

Mario Jeske

Hanno Wild

Ingo Flamme

Friederike Stoll

Hartmut Beck

Mark Meininghaus

Felix Oehme

Metin Akbaba

Alexander Kuhl

Martina Klein

Reiner Fischer

Andreas Turberg

Peter Jeschke

Olga Malsam

Ulrich Görgens

Frank Wunder

Achim Harder

Christian Arnold

Ulrich Rosentreter

Robert Velten

Hanna Tinel

Kerstin Henninger

Peter Nell

Johannes Köbberling

Erich Sanwald

Haruka Shimizu

Michael Härter

Nicole Diedrichs

Klaus Münter

Barbara Albrecht

Dirk Brohm

Sabine Arndt

Frank Memmel

Kilian Tellmann

Arnel B Concepcion

Michael Sebek

Heike Ehrich

Jens Ergüden

Susanne Zuleger

The present invention relates primarily to processes conducted in a continuously operated reactor for preparing particular phosphorus-containing &#x3b1;-aminonitriles of the formulae (Ia) and (Ib) defined hereinafter from corresponding phosphorus-containing cyanohydrin esters and to the use thereof for preparation of glufosinate or of glufosinate salts. The present invention further relates to a process for producing glufosinate/glufosinate salts.

Method for preparing phosphorus-containing &#x3b1;-aminonitriles

The present invention relates primarily to processes for preparing particular phosphorus-containing &#x3b1;-aminonitriles of the formulae (Ia) and (Ib) defined hereinafter from corresponding phosphorus-containing cyanohydrin esters and to the use thereof for preparation of glufosinate or of glufosinate salts. The present invention further relates to a process for preparing glufosinate or glufosinate salts.

Process for preparing phosphorus-containing alpha-aminonitriles

Process for the preparation of triazinyl-substituted oxindoles of formula (3) and salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3&#x2033;) and the use of both for producing crop protection agents.

Method for producing triazinyl-substituted oxindoles

Process for the selective N-sulfonylation of oxindoles, in particular process for the N-sulfonylation of 3-triazinyloxindoles, and also N-sulfonyl-substituted 3-triazinyloxindoles and the use of N-sulfonyl-substituted oxindoles and of N-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.

Method for producing N-sulfonyl-substituted oxindoles

A process is described for preparing 4-haloalkyl-3-mercapto-substituted 2-hydroxybenzoic acid derivatives of the general formula (I) by reaction of 4-thio-substituted &#x3b2;-keto esters of the formula (II) with alkoxyvinyl haloalkyl ketones of the formula (III) in the presence of a base. In the above formulae, X, R, Rand Rare each hydrogen, halogen, alkyl, alkoxy and cycloalkyl.

Method for producing 4-haloalkyl-3-mercapto-substituted 2-hydroxy-benzoic acid derivatives

The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4): where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W): in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above &#x2212;65&#xb0; C. In a subsequent process, this compound is further reacted in the presence of an acid catalyst to give the indole of formula (7) or the oxindole of formula (8): 

Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses

The present application relates to a process based on the oxidative ring opening of a compound with oxindole structure for preparation of substituted 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) proceeding from N-sulfonyl-substituted 3-triazinyloxindole of the formula (2-1), and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) thus prepared, and to the use thereof as intermediates for the synthesis of fine chemicals and of active ingredients in the agricultural sector. The invention also relates to a multistage process for preparation of N-alkyl-N-[2-(1,3,5-triazin-2-ylcarbonyl)phenyl]alkanesulfonamides of the formula (4-1), proceeding from a 3-(alkylsulfanyl)-1,3-dihydro-2H-indol-2-one of the formula (7-1), wherein the multistage process also comprises, as a component step, the oxidative ring opening mentioned, and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) which are obtained by the oxidative ring opening and are used as intermediates in the multistage process.

Method for producing 2-(triazinylcarbonyl) sulfonanilides

The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases

The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

Substituted phenylaminothiazoles and use thereof

Process for preparing 1,3-dihydro-2H-indol-2-ones, starting from thioalkyl-, or thiocycloalkyl-substituted indol-2-one compounds, involving Use of the inventively prepared 1,3-dihydro-2H-indol-2-one as intermediates for the synthesis of fine chemicals and active ingredients from pharmacy and/or agriculture.

Process for preparing substituted 1,3-dihydro-2H-indol-2-ones

The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

Cyclically substituted furopyrimidine derivatives and use thereof

Dipyridyl-dihydropyrazolones and their use

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Hofheim am Taunus, Germany

Gunter Karig