Bayer Aktiengesellschaft

Miles Inc.

Gunter Franke

Wolfgang Harms

Peter Wild

Roderich Raue

Klaus Wunderlich

Ronald G Sommer

Michael Salvati

Dieter Ockelmann

Edgar Siegel, Deceased

A composition, test device and method of determining the presence or concentration of proteins, such as albumin, in a liquid test sample, such as urine. The test device includes a test pad with a carrier matrix incorporating a indicator reagent composition capable of interacting with proteins to produce a detectable response. The indicator reagent composition includes an indicator dye that is capable of interacting with albumin and undergoing a detectable color transition; a buffer; a hydrophobic polymeric compound having the general structural formula: ##STR1## wherein A is ##STR2## and PO is an oxypropylene unit, EO is an oxyethylene unit, y is a number in the range of 0 to about 20, z is a number in the range of 0 to about 20, the sum y+z is a number in the range of about 2 to about 20, and R.sub.2 and R.sub.3 are selected, independently, from the group consisting of hydrogen, an alkyl group, an aralkyl group, and an aryl group; R.sub.1 is either methylene or oxygen; n is a number in the range of one to about 8; and E is hydrogen or methylol when R.sub.1 is methylene, or E is hydroxy when R.sub.1 is oxygen; and a suitable carrier which is water. The indicator reagent composition provides an improved color resolution in the test samples raving negative protein and trace amount of protein.

Composition and device for urinary protein assay and method of using the

Basic dyestuffs of the formula ##STR1## or tautomeric forms thereof, wherein

Water soluble basic dyestuffs

Dyestuffs of the formula ##STR1## wherein F stands for an organic chromophore and

Basic dyestuffs

A process for the preparation of dioxazine compounds of the formula ##STR1## in which B.sub.1 and B.sub.2 designate a ring system with 1, 2, 3 or 4 carbocyclic and/or heterocyclic rings which can be substituted, and

Preparation of dioxazine compounds

Basic triphendioxazine dyestuffs of the formula ##STR1## wherein R.sub.1 and R.sub.2, independently of each other, each denote hydrogen, halogen, alkyl, cyclohexyl, aryl, alkoxy, aryloxy, CN, CONH.sub.2, CONH-alkyl, CON(alkyl).sub.2, CONH-aryl, COOalkyl, NH--CO-alkyl, NH--CO-aryl or NH-aryl and

Basic triphendioxazine dyestuffs

Basic triphendioxazine dyestuffs of the formula ##STR1## wherein Q denotes the radical ##STR2## or hydrogen, R.sub.1 and R.sub.2, independently of each other, denote hydrogen, halogen, alkyl, aryl, alkoxy, aryloxy, CN, CONH.sub.2, CONH--alkyl, CON(alkyl).sub.2, CONH--aryl, COO--alkyl, NH--CO--alkyl or NH--CO--aryl and

Growing community of inventors

Leichlingen, Germany

Gunter Franke