Rotta Research Laboratorium

Sanol Schwarz-Monheim Gmbh

Labtec Gesellschaft Fur Biotechnologische Forschung Und Entwicklung Mbh

Sanol Schwarz-Monhein Gmbh

Gunter Cordes

Lucio C Rovati

Ulrich Munch

Ewald Giesselmann

Francesco Makovec

Luigi A Rovati

Klaus Sandrock

Wilfried Fischer

Ulrike Vollmer

Preparation with an acrylic-based, adhesive copolymeric matrix for the

Plaster for the treatment of nail mycoses

Transdermal therapeutic system for application of pharmaceuticals onto

The present invention is related to a new process for selectively preparing isosorbide-5-nitrate (1.4-3.6-dianhydrosorbitol-5-nitrate) by subjecting isomannide (1.4-3.6-dianhydromannitol) in an organic solvent or an aqueous-organic reaction medium to reaction with the equivalent amount of an acid halogenide or the anhydride of a benzene or naphthalene sulfonic acid possibly substituted by lower alkyl, lower alkoxy and/or halogen, of a perfluoro - lower alkane-sulfonic acid, of a lower alkanesulfonic acid or of a perfluoro - lower - alkanoic acid or with the equivalent amount of an acid halogenide of a carbamic acid or of sulphurous acid; subjecting the resulting isomannide-2-ester in the presence of a solvent and possibly with heating, to reaction with an alkali metal salt or an ammonium salt of a benzoic acid possibly substituted by lower alkyl, lower alkoxy and/or halogen or of a lower alkanoic acid; converting the hydroxy group in the 5-position of the resulting isosorbide-2-ester into the nitric acid ester group in manners known per se by reaction with nitric acid; and subjecting the resulting isosorbide-2-ester-5-nitrate to selective hydrolysis and/or reesterification in an organic or aqueous-organic solvent with an alkali metal hydroxide in manners known per se.

Process for selectively producing isosorbide-5-nitrate

Transdermal medication system for isosorbide dinitrate

Supersaturated aqueous to organic solvent solution of isosorbide dinitrate, process of preparation at elevated temperatures, and use of the supersaturated solutions for the production of infusion solutions.

Supersaturated isosorbide dinitrate solution, process for its production

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Leichlingen, Germany

Gunter Cordes