Dynamit Nobel Aktiengesellschaft

Gunter Bison

Klaus Thewalt

Wolfgang Wolfes

Walter Heinzelmann

Norbert Linkat

Josef Winterscheid

Hans Leuck

Gerhard Schmeling

Reiner Elfgen

Heinz Egger

Johannes Schlupp

Hans-Jorg Westerman

Hans Schubel

Kurt Breideneichen

5-Methyltetrazole can be produced by reacting acetonitrile with an alkali azide or ammonium azide in high purity and a yield of above 98% by using a trialkyl amine as the solvent or suspension agent and by using the associated hydrochloride of the amine as the catalyst.

Process for the production of 5-methyltetrazole

A safe production of sodium nitro-1,3-propanediol from a reaction solution of nitromethane and paraformaldehyde in methanol by addition of sodium methylate is achieved by evaporative cooling of the methanol; it being possible to maintain reaction temperatures of 35.degree. C. to 50.degree. C.

Process for producing the sodium salt of 2-nitro-1,3-propanediol

It is suggested to produce 5-chloro-1H-tetrazolecarboxylic acid esters by reaction of dichloroisonitriloacetic acid esters with alkali or metal azides or ammonium azide. The dichloroisonitriloacetic acid esters required for this purpose are formed by reacting N-formylaminocarboxylic acid esters with chlorine or with compounds which split off chlorine.

Process for the preparation of dichloroisonitrilocarboxylic acid esters

2-Aminopropanediol-1,3 (serinol) can be prepared by hydrogenation of the alkali salt of 2-nitro-1,3-propanediol with assuredly high yields by maintaining a narrow range of temperatures of extending from 50.degree.-80.degree. C. by use of a cooling device.

Process for the preparation of 2-aminopropanediol-1,3(serinol)

A process for the preparation of 1H-tetrazole-1-acetic acid or its ester which comprises contacting trimethylsilyl azide with an orthocarboxylic acid ester of the formula

Process for the preparation of 1H-tetrazole-1 compounds using

A process for the preparation of racemic phenylethylamine which comprises contacting an optical antipode therefore, e.g., L(-) or D(+)-1-phenylethylamine with sodium amide or sodium hydride.

Method of racemizing optically active 1-phenylethylamine

A process for splitting the L-(-)-.alpha.-phenylethylamine salt of D-(-)-.alpha.-azidophenylacetic acid which comprises the steps of mixing the salt with a liquid diluent and an acidic cation exchange material, effecting agitation of the resulting admixture and therefore isolating a highly purified D-(-)-.alpha.-azidophenylacetic acid. This acid product is characterized by an amine content of less than 0.2% by weight.

Process for splitting the L-(-)-.alpha.-phenylethylamine salt of

L(+)- or D(-)-.alpha.-azidophenylacetic acid is produced by a process which involves the steps of reacting a water-soluble salt of DL-.alpha.-azidophenylacetic acid with a water-soluble salt of an optically active .alpha.-phenylethylamine in an aqueous medium, effecting crystallization of the resulting reaction product, that is, the diastereomeric salt, and splitting of the thus-obtained salt.

Process for obtaining D(-)-and L(+)-.alpha.-azidophenylacetic acid

Process for producing tetrazole-1-acetic acid of maximum purity includes the steps of providing a crude reaction product containing an alkyl ester of tetrazole-1-acetic acid having from 1 to 4 carbon atoms in the alkyl group, effecting molecular distillation of this reaction product at a temperature below 130.degree.C. under a vacuum of 10.sup.-.sup.1 torr to obtain a distillant containing the alkyl ester and then gently hydrolyzing the resultant distillate to obtain the desired acid product.

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Troisdorf-Sieglar, Germany

Gunter Bison