Astrazeneca Ab

Isofol Medical Ab

Gunnel E Sundén

Bengt Gustavsson

Anders Vedin

Per L Lindberg

Sverker Von Unge

William Bert Geiss

Anders Lehmann

Karin Lövqvist

David Noreland

Ingvar Ymén

Kevin Fitzpatrick

Karin Ganlöv

Magnus ÖStberg

The present invention relates to the treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC), which involves administering the diastereomerically pure folate adjuvant [6R]-5,10-methylenetetrahydrofolate in 5-fluorouracil (5-FU) based chemotherapy.

[6R]&#x2014;MTHF&#x2014;an efficient folate alternative in 5-fluorouracil based chemotherapy

The present invention relates to the treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC), which involves administering multiple boluses of the diastereomerically pure folate adjuvant [6R]-5,10-methylenetetrahydrofolate in 5-fluorouracil (5-FU) based chemotherapy.

[6R]-MTHF multiple bolus administration in 5-fluorouracil based chemotherapy

The present invention relates to a novel crystalline form of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, known under the generic name omeprazole. Further, the present invention also relates to the use of the novel crystalline form of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H -benzimidazole for the treatment of gastrointestinal disorders, pharmaceutical compositions containing it as well as processes for the preparation of the novel crystalline form of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole.

Crystalline form of omeprazole

Novel compounds of formula (I) wherein Rrepresents hydrogen; Rrepresents hydroxy, fluoro, or an oxo group; Rrepresents hydrogen; Rrepresents hydrogen; and pharmaceutically acceptable salts, solvates, and the stereoisomers thereof, with the exception of the racemate of (3-amino-2-hydroxypropyl)sulphinic acid. The compounds are useful in therapy, especially for the treatment of reflux disease. The invention is also related to processes for their preparation, intermediates of said process and pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy

Compounds useful in reflux disease

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Göteborg, Sweden

Gunnel E Sundén