Other

Gunnar Lindahl

Pharmacia Lkb Biotechnology Ab

Minervax Aps

Hightech Receptor Ab

Margaretha Stalhammar-Carlemalm

Lars Stenberg

Lars Bjorck

Goran Kronvall

Thomas Areschoug

Elisabet Frithz

Lars-Olof Heden

Charlotte Larsson

William H Kastern

The present invention relates to the fields of microbiology and vaccine technology, and concerns the development of a vaccine capable of conferring immunity to group Binfections. More particularly, the present invention relates to a novel fusion protein, comprising N-terminal region fragments of group Bsurface proteins, which confers immunity to invasive strains of the group B. It further pertains to an isolated nucleotide sequence encoding said fusion protein; a vector; a host cell; a vaccine; and a method for preventing or treating a group Binfection.

Fusion protein vaccine

A polypeptide is described herein which comprises (a) the sequence of SEQ ID No. 2, (b) a variant of (a) which is capable of generating a protective immune response to, or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is capable of generating a protective immune response to, in the manufacture of medicament for use as a vaccine against. A pharmaceutical composition for use in vaccinating againstor Group Bcomprises a polypeptide which comprises: (A) the amino acid sequence of SEQ ID No. 2, (B) a variant of (A) which is capable of conferring protective immunity toor Group B, or (C) a fragment of (A) or (B) of at least 6 amino acids in length which is capable of conferring protective immunity toor Group B

Vaccine composition

This invention relates to a new protein, designated Rib, and subfragments, multiples or variants thereof, which confers protective immunity against infection with many group B streptococcal strains, in particular those of serotype III. The invention includes a procedure for purification of the protein, a procedure for preparation of highly specific antibodies, a reagent kit, a DNA sequence encoding the protein and a pharmaceutical composition comprising the protein or fragments or variants thereof.

Protein rib, a cell surface protein that confers immunity to many strains of the group B Streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition

Protein rib, a cell surface protein that confers immunity to many

This invention relates to a new prote in subfragments thereof with affinity for immunoglobulin A, a process for cloning and expression of the protein, the corresponding vectors and hosts, a process for preparing the organism, a method for preparing the protein, a reagent kit and a pharmaceutical composition comprising the protein or fragments thereof.

Protein Arp, with immunoglobulin A binding activity, the corresponding

A hybrid DNA molecule is disclosed by this invention capable of cellular expression comprising the DNA sequence for protein G. Said DNA sequence has substantially the same IgC binding properties as naturally occurring protein G. The molecule may be comprised of DNA sequences coding for fragments of protein G. Moreover, said DNA sequence may code for both fragments of protein G and protein G. The DNA sequence can be isolated from streptococcal DNA.

Protein G and/or fragments thereof

Growing community of inventors

Lund, Sweden

Gunnar Lindahl