Gyros Ab

Gyros Patent Ab

Gunnar Ekstrand

Per X Andersson

Gunnar Thorsen

Gérald Jesson

Helene Derand

Arvi Aksberg

Sussanne Wallenborg

Derand Helene

Gerald Jesson

Ulrike Selditz

Ebru Togan-Tekin

Björn Berg

A rotatable microfluidic device that comprises a hydrophilic microchannel structure in which there is a) an upstream microcavity I with a liquid outlet I, b) a microconduit I connected to liquid outlet I, and c) a capillary valve I associated with microconduit I. The inlet end of the microconduit is closer to the spin axis than the outlet end of the microconduit. The difference in radial distance between the inlet end and the outlet end of microconduit I is typically &#x2267;5%, such as &#x2267;10% or &#x2267;100% or &#x2267;500%, of the difference in radial distance between the uppermost part of the upstream microcavity and liquid outlet I.

Liquid plugs

A microfluidic device () comprising a hydrophilic microchannel structure () in which there is a functional unit that comprises a microconduit I () in which there is an inlet end (), an outlet end (), and a capillary stop function I () in the form of a local non-wettable surface area (). The capillary stop function () defines a segment of microconduit I (). Microconduit I () is within at least a part of this segment () divided into two or more microchannels (). A part of the non-wettable surface area () is associated with an inner wall of each of the microchannels ().

Microfluidic device with finger valves

A microfluidic device comprising a hydrophilic microchannel structure in which there is a functional unit that comprises a microconduit which a) is intended for the transportation of liquid aliquots, and b) has an inlet end and an outlet end between which there is a capillary valve I, which preferably is based on the presence of a local non-wettable surface area. Microconduit I further comprises one or more additional capillary valves, typically one. At least one of the additional valves is upstream of capillary valve I, such as at the inlet end of the microconduit.

Microfluidic device with serial valve

A liquid router that comprises an inlet microconduit that branches into two exit microconduits (microconduit I and II) and is present in a microchannel structure of a microfluidic device which is using centrifugal force created by spinning the device about a spin axis for transporting liquid. The router is characterized in comprising a microcavity in which there are: a lower part comprising two exit openings (exits I and II), and an upper part comprising an inlet opening to which the inlet microconduit () is connected, and microconduits I and II which are connected to exits I and II, respectively, and stretch from a shorter radial position to a larger radial position relative to the spin axis. Microconduit II has a reduced hydrophilicity (=reduced apparent wettability) compared to microconduit I.

Liquid router

A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).

Retaining microfluidic microcavity and other microfluidic structures

A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances. The invention also refers to several other substructures. The substructure are primarily adapted for transporting liquid aliquots that have a surface tnsion &#x3e;5 mN/m with centrifugal force.

Structural units that define fluidic functions

Microstructure for fluids provided in a rotatable disc (D) having a U-shaped volume-defining structure () connected at its base to an inlet arm of a U-shaped chamber ().

Growing community of inventors

Uppsala, Sweden

Gunnar Ekstrand