Leland Stanford Junior University

Johns Hopkins University

The United States Government As Represented by the Department of Veterans Affairs

Gundeep Dhillon

Geoffrey C Gurtner

Jayakumar Rajadas

Gregg L Semenza

Mark R Nicolls

Xinguo Jiang

Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.

HIF-1 modulator paint formulation and uses thereof

Growing community of inventors

Stanford, CA, United States of America

Gundeep Dhillon