Korea Research Institute of Chemical Technology

Korea Basic Science Institute

Gun Hwan Kim

Young Ki Lee

Seung Il Kim

Bo Keun Park

Edmond Changkyun Park

Jeong Hwan Han

Taek Mo Chung

Sang-Yeop Lee

Ji Woon Choi

The present invention relates to a biomarker for diagnosis of overactive bladder (OAB) disease, and a method for screening a drug using the biomarker. The markers described in the present invention can effectively detect or diagnose the onset of OAB by distinguishing them from normal populations. In particular, OAB-specific protein markers released into urine enable simple and rapid OAB diagnosis in a non-invasive manner. In addition, by selecting an agent that changes, particularly normalizes the expression and activity of the markers selected in the present invention, more effective preventative or therapeutic agents of OAB disease can be screened.

Biomarker for diagnosing overactive bladder disease and screening method of therapeutic agents using the same

There are provided a variable resistance memory device and an operating method thereof. In a method for operating a variable resistance memory device, the method includes programming multi-bit data in a multi-bit variable resistance memory cell of the variable resistance memory device, wherein the programming includes: generating sequentially increased program voltage pulses, based on the multi-bit data; and applying the program voltage pulses to the multi-bit variable resistance memory cell, wherein a current-voltage curve of the multi-bit variable resistance memory cell exhibits a self-compliance characteristic, wherein the program voltage pulses are included in a voltage section having the self-compliance characteristic.

Variable resistance memory device and operating method thereof

Growing community of inventors

Daejeon, South Korea

Gun Hwan Kim