Boehringer Ingelheim (canada) Ltd.

Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Gmbh

Gulrez Fazal

Pierre Louis Beaulieu

George Kukolj

James Gillard

Jean Rancourt

Volkhard Austel

Marc-Andre Poupart

Martin Poirier

Sylvie Goulet

Youla S Tsantrizos

Eric Jolicoeur

Bounkham Thavonekham

Murray D Bailey

Bruno Simoneau

Marc-André Poupart

Serge R Landry

Pierre Lavallee

Timothy A Stammers

Josee Bordeleau

Rene Coulombe

René Coulombe

Tim Stammers

Steve Mason

William Ogilvie

Josée Bordeleau

Compounds of formula I: wherein X, R, R, Rand Rare defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

Viral polymerase inhibitors

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: wherein Rand Rand Q are as defined herein;

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: wherein:

A compound of the formula I: wherein: X is CH or N; Y is O or S; Z is OH, NH, NMeR, NHR; ORor 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S, said heterocycle being optionally substituted with from 1 to 4 substituents; A is N, CORor CR, wherein Ris H, halogen, or (C) alkyl and Ris H or (Calkyl), with the proviso that X and A are not both N; Ris H, halogen, (Calkyl) or OR, wherein Ris H or (Calkyl); The compounds of the invention may be used as inhibitors of hepatitis C virus replication. The invention further provides a method for treating or preventing hepatitis C virus infection.

Compounds or enantiomers of formula (I) or a salt thereof: wherein R, R, R, Rand Rare as defined herein, are useful for the manufacture of a medicament for the treatment or prevention of respiratory syncytial virus infection in a mammal.

RSV polymerase inhibitors

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I:wherein Ris selected from: H, haloalkyl, (C)alkyl, (C)alkenyl, (C)cycloalkyl, (C)alkynyl, (C)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted;

Peptidomimetic inhibitors of the human cytomegalovirus protease

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Roxboro, Canada

Gulrez Fazal