Napo Pharmaceuticals, Inc.

Aradigm Corporation

Napo Pharmaceutcials, Inc.

Gul P Balwani

Atul S Khandwala

Jody Wai-Han Chan

David F Sesin

Edward James Rozhon

Akram Sabouni

Brooks M Boyd

John Whatley

Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from aspp. or aspp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. The invention also relates to methods of producing a directly compressible proanthocyanidin polymer composition, as well as compositions containing the directly compressible proanthocyanidin polymer composition.

Compositions and methods of treatment with proanthocyanidin polymer antidiarrheal compositions

Method of treating secretory diarrhea with enteric formulations of proanthocyanidin polymer

Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

Stable aqueous formulations which are free of products derived from human or animal origin and which maintain high biological activity and high chemical and physical stability of alpha-type interferon for an extended period of time. Methods of producing stable aerosol formulations of the same for delivery to the lungs are also provided, as well as systems and methods of delivering the formulations to the lungs for systemic absorption.

Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b

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Fremont, CA, United States of America

Gul P Balwani