Board of Trustees of the University of Arkansas

Guillermo Tellez-Isaias

Billy M Hargis

Srichaitanya Shivaramaiah

Neil R Pumford

Marion Morgan

Amanda Wolfenden

Lisa Bielke

Kyle Dean Teague

Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.

Mucosal adjuvants and delivery systems

Provided herein are compositions including a probiotic including at least one strain of live bacteria and a Marek's Disease vaccine. Compositions including a probiotic or a probiotic and a Marek's Disease vaccine may be administered to subjects, including poultry. The compositions may be administered in ovo to increase early lactic acid bacteria in the gastrointestinal tract of the subject, to decrease the gram negative bacteria in the gastrointestinal tract of the subject, to reduce the level ofin the gastrointestinal tract of the subject and to increase the body weight gain of the subject. Also provided are kits including a probiotic and a Marek's Disease vaccine.

Poultry probiotic vaccine compositions and methods of use thereof

Growing community of inventors

Fayetteville, AR, United States of America

Guillermo Tellez-Isaias