The General Hospital Corporation

Canon U.s.a., Inc.

Massachusetts Institute of Technology

Infraredx, Inc.

Vanguard Imaging Ltd.

California Institute of Technology

University of Colorado

Boston University

Harvard College

The UAB Research Foundation (the University of Alabama at Birmingham)

Massachusetts Eye and Ear Infirmary

The General Hospital Corpoation

Guillermo J Tearney

Dukho Do

George M Whitesides

Hao Wang

Brett Eugene Bouma

Dvir Yelin

Milen Stefanov Shishkov

Joseph A Gardecki

Benjamin J Vakoc

Dongkyun Kang

Seok-Hyun Yun

Johannes Fitzgerald De Boer

Mitsuhiro Ikuta

Nicusor V Iftimia

Linbo Liu

Kengyeh Ken Chu

Kanwarpal Singh

Norman S Nishioka

Wang-Yuhl Oh

James G Fujimoto

Farouc Amin Jaffer

Yogesh Verma

David Odeke Otuya

Seok-Hyun (Andy) Yun

Wang-Yuhl (William) Oh

Robert Carruth

Simon M Furnish

Andres Zuluaga

Tao Wu

Jing Tang

S Eric Ryan

Chulho Daryl Hyun

Hongki Yoo

Michalina Gora

Li Li

Roman Shubochkin

Theodore Morse

Robert O Kenet

Melissa Suter

Kevin Gallagher

Romain Luu

Chia-Pin Liang

Jiheun Ryu

Jing Dong

Changhuei Yang

Robert R McLeod

Robert H Webb

Eric Arthur Swanson

Jacob Schieffelin Brauer

Xiquan Cui

Seemantini K Nadkarni

Eric J Sorscher

Steven Mark Rowe

Ali Motafakker-Fard

Stephen A Boppart

Mark Brezinski

Barney J Kenet

Jenny Sauk

Kevin Woods

Moon Gu Lee

John A Evans

Nima Tabatabaei

Christopher Max Colice

Biwei Yin

Jinyong Ha

Barry Vuong

Hamid Farrokhi

Minkyu Kim

Adrien E Desjardins

Timothy Nehiley Ford

Johannes deBoer

Weina Lu

Paulino Vacas Jacques

Constantinos Pitris

Bradford James Diephuis

Mireille Rosenberg

Eric James Wilsterman

Gregory Andrew Dierksen

Rohith K Reddy

William C Warger, Ii

Raymond C Chan

Daisuke Yamada

Kenji Yamazoe

Eman Namati

Konstantina Stankovic

Tzu-Yu Wu

Anderson Thi Mach

Mie Kunio

Ramses V Martinez

Adrien Desjardins

Saumil N Merchant

Wang Yuhl Oh

John Rosowski

Jose Luis Guerrero

Markus Daniel Herrmann

Seok Hyun Yun

Jason T Motz

An apparatus for obtaining image data and functional data from a biological sample, the apparatus including: an interferometer configured to acquire interferometric information at a plurality of time points along an imaging plane for which at least one axis of the plane is at least partially along a depth or axial dimension that is based on radiations provided from a reference interfered with by the biological sample; and a processor configured to receive the interferometric information from the interferometer and configured to: process the interferometric information to generate an image of the biological sample along the imaging plane; determine frequency information based on the plurality of time points of the interferometric information, the frequency information reflecting temporal modulations induced by dynamic functions of the biological sample; generate a spatial map of the frequency information, and the spatial map of the frequency information indicating the dynamic functions of the biological sample.

System and method of dynamic micro-optical coherence tomography for mapping cellular functions

In some embodiments, devices, systems, and methods for cryogenic biopsy sampling are provided. In some embodiments, a device for cryogenic biopsy sampling is provided, the device including: a dual lumen tube; an elongated probe tip coupled to the distal end of the dual lumen tube, with a first lumen extending into a hollow portion in the tip and a second lumen in fluid communication with the hollow portion; a first port in fluid communication with the first lumen; a second port in fluid communication with the second lumen, wherein the first lumen, the elongated probe element, and the second lumen provide a closed pathway through which a substance introduced through the first port can flow through the first lumen into the elongated probe element, and out of the elongated probe element through the second lumen to the second port.

Devices, systems, and methods for cryogenic biopsy sampling

A method of correcting distortion of an image, including: analyzing, by a processor, an image segment of the image to identify a speckle artifact, the image segment being obtained from a scanning imaging device; determining, by the processor, an aspect ratio of a shape of the speckle artifact; determining, by the processor, a correction factor for the shape of the speckle artifact based on the aspect ratio; and adjusting, by the processor, a dimension of the image segment based on the correction factor.

Speckle-based image distortion correction for laser scanning microscopy

Exemplary apparatus and method can be provided. For example, using at least one light source first arrangement, it is possible to provide pulses of light to at least one portion of a biological structure. At least one detector second arrangement can be used to detect images from the portion(s) based on the pulses, and provide data based on the detection. With at least one configuration, it is possible prevent and/or reduce a movement of the apparatus within at least one anatomical body (i) is a particular surface of the apparatus, (ii) covers at least one portion of the surface, and/or (iii) extends from the surface. In addition or alternatively, with at least one computer third arrangement, it is possible to receive the data, and control a timing of at least one of activation or deactivation of at least one portion of the first arrangement based on the data.

Method and apparatus for recording microscopic images from within a living organism using an implantable device

Apparatus and method can be provided for obtaining at least one anatomical sample. For example, it is possible to provide and insert a housing into a body or provided on a hydrated anatomical structure. Further, with a source, it is possible to emit an electromagnetic radiation which causes at least the anatomical sample(s) to attach to at least one portion of the housing. A compound can be provided on a surface of the housing, and the source provides the radiation to the compound and changes properties thereof to be adhesive. The source can provide the radiation to the housing, and can change properties of a surface thereof to be adhesive. A component can be provided on a surface of the anatomical structure, and the source provides the radiation to the compound and changes properties thereof to be adhesive.

Apparatus, method and computer-accessible medium for obtaining tissue samples

In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.

Devices, systems, and methods for advancing and positioning tethered capsule microendoscopes

In some embodiments, systems, methods, and media for capsule-based multimode endoscopy are provided. In some embodiments, a probe for capsule-based multimode endoscopy is provided, the probe comprising: a rigid capsule; a flexible tether coupled to a proximal end of the capsule; a rotatable reflective surface disposed within the capsule; a static ball lens disposed within the capsule; a first optical fiber optically coupled to the ball lens, the first optical fiber passing through the flexible tether; a second optical fiber optically coupled to the ball lens, the second optical fiber passing through the flexible tether; a graded index fiber disposed between a distal end of the second optical fiber and the ball lens, the graded index fiber optically coupled to the second optical fiber and the ball lens.

Systems, methods, and media for capsule-based multimode endoscopy

An optical coherence tomography (OCT) imaging tool including an optical waveguide having a proximal end and a distal end, at least a portion of the optical waveguide disposed at the distal end of the optical waveguide having an increased elasticity than a proximal portion of the optical waveguide; a sheath surrounding at least a portion of the optical waveguide; and an optical probe coupled to the optical waveguide, the optical probe including: an optical element coaxially aligned with a central axis of the distal end of the optical waveguide, the optical element being configured to rotate about the central axis and redirect light emitted by the optical waveguide toward a circumference of the optical probe from the central axis, and the focusing element being disposed within a housing.

Systems and methods for micro-optical coherence tomography imaging of the cochlea

An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.

Apparatus, methods and computer-accessible media for in situ three-dimensional reconstruction of luminal structures

In some embodiments, systems, methods, and media for multiple reference arm spectral domain optical coherence tomography are provided which, in some embodiments, includes: a sample arm coupled to a light source; a first reference arm having a first path length; a second reference arm having a longer second path length; a first optical coupler that combines light from the sample arm and the first reference arm; a second coupler that combines light from the sample arm and the second reference arm; and an optical switch comprising: a first input port coupled to the first optical coupler; a second input coupled to the second coupler via an optical waveguide that induces a delay at least equal to an acquisition time of an image sensor; and an output coupled to the image sensor.

Systems, methods, and media for multiple reference arm spectral domain optical coherence tomography

One or more devices, systems, methods, and storage mediums using artificial intelligence application(s) using an apparatus or system that uses and/or controls one or more imaging modalities, such as, but not limited to, angiography, Optical Coherence Tomography (OCT), Multi-modality OCT, near-infrared fluorescence (NIRAF), OCT-NIRAF, etc. are provided herein. Examples of AI applications discussed herein, include, but are not limited to, using one or more of: AI coregistration, AI marker detection, deep or machine learning, computer vision or image recognition task(s), keypoint detection, feature extraction, model training, input data preparation techniques, input mapping to the model, post-processing, and/or interpretation of output data, one or more types of machine learning models (including, but not limited to, segmentation, regression, combining or repeating regression and/or segmentation), marker detection success rates, and/or co-registration success rates to improve or optimize marker detection and/or co-registration.

Artificial intelligence coregistration and marker detection, including machine learning and using results thereof

A probe for performing endomicroscopy, including: a light source; a waveguide coupled to the light source; a diffraction grating, the waveguide directing light from the light source to the diffraction grating; and a lens having a first aspheric surface and a second biconic surface, diffracted light from the diffraction grating being directed into the aspheric surface of the lens and being emitted from the biconic surface of the lens towards a transparent cylindrical surface of the probe.

System and method for high-resolution, high-speed capsule endomicroscopy

Exemplary method and apparatus for diagnosing or characterizing an inflammation within an anatomical structure can be provided. For example, using at least one source arrangement, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure at at least one first wavelength in vivo. With at least one detector arrangement, it is possible to detect at least one second electro-magnetic radiation at at least one second wavelength provided from the anatomical structure. The second radiation can be associated with the first radiation, and the first wavelength can be shorter than the second wavelength. The second radiation can be provided from the anatomical structure due to at least one change in the anatomical structure caused by the inflammation without providing an artificial fluorescence substance. At least one computer arrangement can be used to determine at least one characteristic of the structure based on the second radiation to diagnose or characterize the inflammation within the anatomical structure.

Apparatus, devices and methods for in vivo imaging and diagnosis

Growing community of inventors

Cambridge, MA, United States of America

Guillermo J Tearney